Clinical Center of Vojvodina, Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia.
Department of Physiology and Biophysics, School of Medicine, Case Western Reserve University, Cleveland, Ohio, United States.
Curr Vasc Pharmacol. 2018;16(6):610-617. doi: 10.2174/1570161115666170821154841.
Obesity and micronutrient deficiencies contribute to the risk of cardiometabolic diseases such are type 2 diabetes mellitus and Cardiovascular Disease (CVD).
We examined the frequency of concomitant deficit of Magnesium (Mg) and vitamin D in obese patients and evaluated the connection of these combined deficiencies with indicators of cardiometabolic risk in non-diabetic subjects.
Non-diabetic middle aged adults (n = 80; mean age 36 ± 4 years, 52% women) were recruited based on weight/adiposity parameters [i.e. Body Mass Index (BMI) and body fat percentage (FAT%)]. Cardiometabolic risk indicators [insulin resistance (Homeostatic Model Assessment for Insulin Resistance (HOMA-IR)) and CVD risk (Framingham risk score for predicting 10-year CVD)], Mg status (i.e. total serum Mg concentration (TMg), Chronic Latent Mg Deficiency (CLMD) - 0.75-0.85 mmol/L), vitamin D status (i.e. serum concentration of 25-hydroxyvitamin D (25(OH)D), vitamin D deficiency <50 nmol/l) were assessed.
Among obese subjects 36% presented a combination of vitamin D deficiency and CLMD. In all studied patients, 25(OH)D and TMg levels both, individually and combined, showed a negative linear correlation with HOMA-IR and CVD risk. In subjects with CLMD (TMg <0.85 mmol/L), a negative linear coefficient was found between 25(OH)D and, HOMA-IR and CVD risk, compared with subjects with normal TMg status (TMg ≥0.85 mmol/L).
CLMD and vitamin D deficiency may commonly be present in obese non-diabetic subjects. Individually and combined, both deficiencies predispose non-diabetic patients to increased risk of cardiometabolic diseases. Maintaining normal Mg status may improve the beneficial effects of vitamin D on cardiometabolic risk indicators.
肥胖和微量营养素缺乏会增加患 2 型糖尿病和心血管疾病（CVD）等代谢性心血管疾病的风险。
我们研究了肥胖患者同时存在镁（Mg）和维生素 D 缺乏的频率，并评估了这些联合缺乏与非糖尿病患者代谢心血管风险指标的关系。
根据体重/脂肪参数[即体重指数（BMI）和体脂百分比（FAT%）]，招募了 80 名非糖尿病中年成年人（平均年龄 36 ± 4 岁，52%为女性）。代谢心血管风险指标[胰岛素抵抗（稳态模型评估的胰岛素抵抗（HOMA-IR））和 CVD 风险（预测 10 年 CVD 的 Framingham 风险评分）]、Mg 状况（即总血清 Mg 浓度（TMg）、慢性潜伏性 Mg 缺乏（CLMD）-0.75-0.85mmol/L）、维生素 D 状况（即血清 25-羟基维生素 D（25（OH）D）浓度、维生素 D 缺乏症 <50nmol/L）。
在肥胖患者中，有 36%同时存在维生素 D 缺乏和 CLMD。在所有研究患者中，25（OH）D 和 TMg 水平单独和联合均与 HOMA-IR 和 CVD 风险呈负线性相关。在 CLMD（TMg <0.85mmol/L）患者中，与 TMg 正常（TMg≥0.85mmol/L）患者相比，25（OH）D 与 HOMA-IR 和 CVD 风险之间存在负线性关系。
CLMD 和维生素 D 缺乏症可能在肥胖的非糖尿病患者中同时存在。单独和联合时，这两种缺乏都会使非糖尿病患者患代谢性心血管疾病的风险增加。维持正常的 Mg 状态可能会提高维生素 D 对代谢心血管风险指标的有益作用。
