Gutierrez-Ulloa Carlos E, Buyanova Marina Yu, Apartsin Evgeny K, Venyaminova Alya G, de la Mata F Javier, Valiente Mercedes, Gómez Rafael
Departamento de Química Inorgánica, Universidad de Alcalá, Campus Universitario, Alcalá de Henares, Madrid, Spain.
Institute of Chemical Biology and Fundamental Medicine SB RAS, Novosibirsk, Russia.
Org Biomol Chem. 2017 Sep 13;15(35):7352-7364. doi: 10.1039/c7ob01331k.
A novel family of amphiphilic ionic carbosilane dendrons containing fatty acids at the focal point were synthesized and characterized. They spontaneously self-assembled in aqueous solution into micelles both in the absence and presence of salt, as confirmed by surface tension, conductivity, and DLS measurements. Dendron based micelles have spherical shapes and increase in size on decreasing dendron generation. These dendritic micelles have been demonstrated to be able to form complexes with therapeutic macromolecules such as siRNA and show a high loading capacity for drugs such as procaine, suggesting their potential use as nanocarriers for therapeutics.
合成并表征了一类新型的两亲性离子型碳硅烷树枝状分子，其焦点处含有脂肪酸。通过表面张力、电导率和动态光散射测量证实，它们在水溶液中无论有无盐的情况下都会自发地自组装成胶束。基于树枝状分子的胶束呈球形，并且随着树枝状分子代数的降低尺寸增大。这些树枝状胶束已被证明能够与治疗性大分子如siRNA形成复合物，并对普鲁卡因等药物具有高负载能力，表明它们作为治疗用纳米载体的潜在用途。
