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作为一种新方法，功能性两亲树枝状分子的自适应合成用于人工超分子客体。

Adaptive Synthesis of Functional Amphiphilic Dendrons as a Novel Approach to Artificial Supramolecular Objects.

机构信息

Institute of Chemical Process Fundamentals of the CAS, v.v.i., Rozvojová 135, 16502 Prague, Czech Republic.

Faculty of Science, J.E. Purkyně University in Ústí nad Labem, Pasteurova 15, 40096 Ústí nad Labem, Czech Republic.

出版信息

Int J Mol Sci. 2022 Feb 14;23(4):2114. doi: 10.3390/ijms23042114.

DOI:10.3390/ijms23042114
PMID:35216229
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8877797/
Abstract

Supramolecular structures, such as micelles, liposomes, polymerosomes or dendrimerosomes, are widely studied and used as drug delivery systems. The behavior of amphiphilic building blocks strongly depends on their spatial distribution and shape of polar and nonpolar component. This report is focused on the development of new versatile synthetic protocols for amphiphilic carbosilane dendrons (amp-CS-DDNs) capable of self-assembly to regular micelles and other supramolecular objects. The presented strategy enables the fine modification of amphiphilic structure in several ways and also enables the facile connection of a desired functionality. DLS experiments demonstrated correlations between structural parameters of amp-CS-DDNs and the size of formed nanoparticles. For detailed information about the organization and spatial distribution of amp-CS-DDNs assemblies, computer simulation models were studied by using molecular dynamics in explicit water.

摘要

超分子结构，如胶束、脂质体、聚合物胶束或树枝状聚合物胶束，被广泛研究并用作药物传递系统。两亲性构建块的行为强烈依赖于它们的空间分布和极性和非极性成分的形状。本报告重点介绍了新的多功能合成方案，用于能够自组装成规则胶束和其他超分子物体的两亲性碳硅烷树状大分子（amp-CS-DDN）。所提出的策略能够以多种方式对两亲性结构进行精细修饰，并且还能够方便地连接所需的功能。DLS 实验证明了 amp-CS-DDN 的结构参数与形成的纳米颗粒的大小之间的相关性。有关 amp-CS-DDN 组装的组织和空间分布的详细信息，通过在显式水中使用分子动力学研究了计算机模拟模型。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e725/8877797/dc95191d4510/ijms-23-02114-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e725/8877797/41369045945b/ijms-23-02114-sch001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e725/8877797/ee55c00d049a/ijms-23-02114-sch002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e725/8877797/e25f3e674ca4/ijms-23-02114-sch003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e725/8877797/f2eb3441608c/ijms-23-02114-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e725/8877797/dc95191d4510/ijms-23-02114-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e725/8877797/41369045945b/ijms-23-02114-sch001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e725/8877797/ee55c00d049a/ijms-23-02114-sch002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e725/8877797/e25f3e674ca4/ijms-23-02114-sch003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e725/8877797/f2eb3441608c/ijms-23-02114-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e725/8877797/dc95191d4510/ijms-23-02114-g002.jpg

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