通过重氮酮重排-环扩张策略探索韦立他汀核心。
An Approach to the Welwistatin Core via a Diazoketone Rearrangement-Ring Expansion Strategy.
机构信息
Department of Chemistry and State Key Laboratory of Synthetic Chemistry, The University of Hong Kong , Pokfulam Road, Hong Kong, P. R. China.
出版信息
Org Lett. 2017 Sep 1;19(17):4468-4471. doi: 10.1021/acs.orglett.7b01988. Epub 2017 Aug 22.
PMID:28829148
Abstract
The rhodium-catalyzed decomposition of fused bicyclic α-diazo-β-hydroxyketone 16 and rearrangement to 17 is featured in an approach to the bridged bicyclic core of welwistatin. The bicyclic [4.3.1] core of 25 is furnished from a subsequent cyclopropanation to generate 23, followed by its ring expansion.
摘要
铑催化的稠合双环α-重氮-β-羟基酮 16 的分解和重排至 17 的反应是 welwistatin 桥环双环核心构建方法的特点。[4.3.1]双环 25 的核心通过随后的环丙烷化生成 23 来提供，然后进行其环扩张。
Zotero 插件