Department of Endoscopic Diagnosis, General Hospital of Daqing Oil Field, Daqing, Heilongjiang Province, China.
Eur Rev Med Pharmacol Sci. 2017 Aug;21(15):3384-3388.
Helicobacter pylori (HP) infection has been demonstrated to be a risk factor accounting for the initiation and development of gastric cancer (GC). The aim of the present study was to investigate the clinical significance of miR-490-3p in HP associated GC.
We measured the expression level of miR-490-3p in human GC tissues by quantitative Real-time PCR (qPCR). Then the association between miR-490-3p and clinical features of GC was further investigated.
Our results showed that miR-490-3p levels exhibited a progressive downregulation in gastritis, intestinal metaplasia, HP negative GC and HP positive GC. In addition, miR-490-3p expression was significantly correlated with various clinicopathological parameters such as lymph node metastasis and clinical stage in HP-positive GC. Moreover, GC patients with lower miR-490-3p had a shorter 5 years overall/disease free survival time in the HP positive cohort. Finally, multivariate analysis showed that low miR-490-3p was an independent risk factor for HP associated GC.
miR-490-3p is downregulated in HP-positive GC and associated with poor clinical outcome, indicating that miR-490-3p is a promising prognostic biomarker for HP positive GC.
幽门螺杆菌（HP）感染已被证实是导致胃癌（GC）发生和发展的危险因素。本研究旨在探讨 miR-490-3p 在 HP 相关 GC 中的临床意义。
通过实时定量 PCR（qPCR）测量人 GC 组织中 miR-490-3p 的表达水平。然后进一步研究 miR-490-3p 与 GC 临床特征之间的关系。
结果显示，miR-490-3p 水平在胃炎、肠上皮化生、HP 阴性 GC 和 HP 阳性 GC 中呈逐渐下调。此外，miR-490-3p 的表达与 HP 阳性 GC 中的各种临床病理参数如淋巴结转移和临床分期显著相关。此外，在 HP 阳性队列中，miR-490-3p 表达水平较低的 GC 患者的 5 年总生存率/无病生存率较短。最后，多因素分析表明，miR-490-3p 低表达是 HP 相关 GC 的独立危险因素。
miR-490-3p 在 HP 阳性 GC 中下调，并与不良临床结局相关，表明 miR-490-3p 是 HP 阳性 GC 的有前途的预后生物标志物。
