Nagy Balint, Hovhannisyan Anahit, Barzan Ruxandra, Chen Ting-Jiun, Kukley Maria
Group of Neuron Glia Interaction, Werner Reichardt Centre for Integrative Neuroscience, University of Tübingen, Tübingen, Germany.
Graduate Training Centre of Neuroscience, University of Tübingen, Tübingen, Germany.
PLoS Biol. 2017 Aug 22;15(8):e2001993. doi: 10.1371/journal.pbio.2001993. eCollection 2017 Aug.
In the developing and adult brain, oligodendrocyte precursor cells (OPCs) are influenced by neuronal activity: they are involved in synaptic signaling with neurons, and their proliferation and differentiation into myelinating glia can be altered by transient changes in neuronal firing. An important question that has been unanswered is whether OPCs can discriminate different patterns of neuronal activity and respond to them in a distinct way. Here, we demonstrate in brain slices that the pattern of neuronal activity determines the functional changes triggered at synapses between axons and OPCs. Furthermore, we show that stimulation of the corpus callosum at different frequencies in vivo affects proliferation and differentiation of OPCs in a dissimilar way. Our findings suggest that neurons do not influence OPCs in "all-or-none" fashion but use their firing pattern to tune the response and behavior of these nonneuronal cells.
在发育中的大脑和成年大脑中，少突胶质前体细胞（OPCs）受神经元活动的影响：它们参与与神经元的突触信号传递，并且其增殖以及向有髓神经胶质细胞的分化会因神经元放电的短暂变化而改变。一个尚未得到解答的重要问题是，少突胶质前体细胞是否能够区分不同模式的神经元活动并以独特的方式对其做出反应。在此，我们在脑片中证明，神经元活动模式决定了轴突与少突胶质前体细胞之间突触处触发的功能变化。此外，我们表明，在体内以不同频率刺激胼胝体对少突胶质前体细胞的增殖和分化有不同影响。我们的研究结果表明，神经元并非以“全或无”的方式影响少突胶质前体细胞，而是利用其放电模式来调节这些非神经元细胞的反应和行为。
