Department of Molecular Genetics and Cell Biology, University of Chicago, Chicago, IL 60637, USA.
Dev Cell. 2017 Aug 21;42(4):309-311. doi: 10.1016/j.devcel.2017.08.006.
In this issue of Developmental Cell, Dickinson et al. (2017) and Rodriguez et al. (2017), along with Wang et al. (2017) in Nature Cell Biology, show how PAR protein oligomerization can dynamically couple protein diffusion and transport by cortical flow to control kinase activity gradients and polarity in the C. elegans zygote.
在本期《发育细胞》中,Dickinson 等人(2017 年)、Rodriguez 等人(2017 年)和 Nature Cell Biology 上的 Wang 等人(2017 年)展示了 PAR 蛋白寡聚化如何通过皮层流动态偶联蛋白扩散和运输,从而控制 C. elegans 合子中的激酶活性梯度和极性。