Granström M, Thorén M, Blennow M, Tiru M, Sato Y
Eur J Clin Microbiol. 1987 Feb;6(1):18-21. doi: 10.1007/BF02097184.
An acellular pertussis vaccine JNIH-6 containing pertussis toxin and filamentous hemagglutinin was evaluated in adult volunteers with regard to adverse reactions and antibody response. Adverse reactions were few and mild. A late onset local reaction was seen in 22 of the 47 vaccinees (47%) as compared to none of the 20 subjects receiving a placebo, the carrier solution of aluminium phosphate of the vaccine. The reaction, which manifested itself on the 6th to 8th day after vaccination, consisted in all cases of an induration and/or swelling considered insignificant by the majority of the subjects. The reaction was only found in vaccinees receiving a first dose of vaccine and was independent of the prevaccination antitoxin level. The vaccine induced a highly satisfactory antibody response to both filamentous hemagglutinin and pertussis toxin.
对一种含有百日咳毒素和丝状血凝素的无细胞百日咳疫苗JNIH - 6在成年志愿者中进行了不良反应和抗体反应方面的评估。不良反应少且轻微。47名接种疫苗者中有22名（47%）出现了迟发性局部反应，而20名接受安慰剂（疫苗的磷酸铝载体溶液）的受试者均未出现这种情况。该反应在接种疫苗后第6至8天出现，所有病例均表现为硬结和/或肿胀，大多数受试者认为这种情况不严重。该反应仅在接受第一剂疫苗的接种者中出现，且与接种前抗毒素水平无关。该疫苗对丝状血凝素和百日咳毒素均诱导出了非常令人满意的抗体反应。
