铜(II)-双(硫代氨基甲酸盐)配合物作为抗衣原体药物。

Copper(II)-bis(thiosemicarbazonato) complexes as anti-chlamydial agents.

机构信息

The iThree Institute, University of Technology Sydney, 15 Broadway, Ultimo, NSW 2007, Australia.

School of Chemistry and Molecular Biosciences and Australian Centre for Infectious Disease Research, The University of Queensland, St Lucia, QLD 4072, Australia.

出版信息

Pathog Dis. 2017 Sep 29;75(7). doi: 10.1093/femspd/ftx084.

DOI:10.1093/femspd/ftx084

PMID:28830076

Abstract

Lipophilic copper (Cu)-containing complexes have shown promising antibacterial activity against a range of bacterial pathogens. To examine the susceptibility of the intracellular human pathogen Chlamydia trachomatis to copper complexes containing bis(thiosemicarbazone) ligands [Cu(btsc)], we tested the in vitro effect of CuII-diacetyl- and CuII-glyoxal-bis[N(4)-methylthiosemicarbazonato] (Cu(atsm) and Cu(gtsm), respectively) on C. trachomatis. Cu(atsm) and to a greater extent, Cu(gtsm), prevented the formation of infectious chlamydial progeny. Impacts on host cell viability and respiration were also observed in addition to the Chlamydia impacts. This work suggests that copper-based complexes may represent a new lead approach for future development of new therapeutics against chlamydial infections, although host cell impacts need to be fully explored.

摘要

脂溶性含铜（Cu）配合物对多种细菌病原体表现出有希望的抗菌活性。为了研究细胞内人病原体沙眼衣原体对含双（硫代氨基甲酰基）配体的铜配合物的敏感性[Cu（btsc）]，我们测试了 CuII-二乙酰基和 CuII-乙二醛双[N（4）-甲基硫代氨基甲酰基]（Cu（atsm）和 Cu（gtsm），分别）对沙眼衣原体的体外作用。Cu（atsm），更重要的是，Cu（gtsm），阻止了传染性衣原体后代的形成。除了对衣原体的影响外，还观察到对宿主细胞活力和呼吸的影响。这项工作表明，基于铜的配合物可能代表了针对衣原体感染的新型治疗药物开发的新方法，尽管需要充分探索对宿主细胞的影响。