增强血液干细胞植入的努力：来自斑马鱼造血作用的最新见解。

Perlin Julie R, Robertson Anne L, Zon Leonard I

Stem Cell Program and Division of Hematology/Oncology, Boston Children's Hospital, Harvard Stem Cell Institute, Harvard Medical School, Boston, MA.

Stem Cell Program and Division of Hematology/Oncology, Boston Children's Hospital, Harvard Stem Cell Institute, Harvard Medical School, Boston, MA

J Exp Med. 2017 Oct 2;214(10):2817-2827. doi: 10.1084/jem.20171069. Epub 2017 Aug 22.

Hematopoietic stem cell transplantation (HSCT) is an important therapy for patients with a variety of hematological malignancies. HSCT would be greatly improved if patient-specific hematopoietic stem cells (HSCs) could be generated from induced pluripotent stem cells in vitro There is an incomplete understanding of the genes and signals involved in HSC induction, migration, maintenance, and niche engraftment. Recent studies in zebrafish have revealed novel genes that are required for HSC induction and niche regulation of HSC homeostasis. Manipulation of these signaling pathways and cell types may improve HSC bioengineering, which could significantly advance critical, lifesaving HSCT therapies.

造血干细胞移植（HSCT）是治疗多种血液系统恶性肿瘤患者的重要疗法。如果能够在体外从诱导多能干细胞中生成患者特异性造血干细胞（HSC），HSCT将会得到极大改善。目前对于参与HSC诱导、迁移、维持和龛植入的基因及信号的认识尚不完整。斑马鱼的最新研究揭示了HSC诱导和HSC稳态龛调节所需的新基因。对这些信号通路和细胞类型的操控可能会改善HSC生物工程，这有望显著推动关键的、挽救生命的HSCT疗法发展。