Heck Adam M, Ishida Takashi, Hadland Brandon
Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, United States.
Department of Pediatrics, University of Washington School of Medicine, Seattle, WA, United States.
Front Cell Dev Biol. 2020 Nov 13;8:602617. doi: 10.3389/fcell.2020.602617. eCollection 2020.
During embryonic development, sequential waves of hematopoiesis give rise to blood-forming cells with diverse lineage potentials and self-renewal properties. This process must accomplish two important yet divergent goals: the rapid generation of differentiated blood cells to meet the needs of the developing embryo and the production of a reservoir of hematopoietic stem cells to provide for life-long hematopoiesis in the adult. Vascular beds in distinct anatomical sites of extraembryonic tissues and the embryo proper provide the necessary conditions to support these divergent objectives, suggesting a critical role for specialized vascular niche cells in regulating disparate blood cell fates during development. In this review, we will examine the current understanding of how organ- and stage-specific vascular niche specialization contributes to the development of the hematopoietic system.
在胚胎发育过程中，造血作用的连续浪潮产生了具有不同谱系潜能和自我更新特性的造血细胞。这一过程必须实现两个重要但不同的目标：快速生成分化的血细胞以满足发育中胚胎的需求，以及产生造血干细胞库以支持成体的终身造血。胚外组织和胚胎本身不同解剖部位的血管床提供了支持这些不同目标的必要条件，这表明特定的血管龛细胞在发育过程中调节不同血细胞命运方面起着关键作用。在这篇综述中，我们将探讨目前对于器官和阶段特异性血管龛特化如何促进造血系统发育的理解。
