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间歇低氧对大鼠束状带-网状带细胞分泌皮质酮的刺激作用。

Stimulatory Effect of Intermittent Hypoxia on the Production of Corticosterone by Zona Fasciculata-Reticularis Cells in Rats.

机构信息

Department of Physiology, School of Medicine, National Yang-Ming University, Taipei, 11221, Taiwan.

Department of Nursing, Chang Gung University of Science and Technology, Taoyuan, 33303, Taiwan.

出版信息

Sci Rep. 2017 Aug 22;7(1):9035. doi: 10.1038/s41598-017-07054-6.

DOI:10.1038/s41598-017-07054-6
PMID:28831034
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5567345/
Abstract

Hypoxia or intermittent hypoxia (IH) have known to alter both synthesis and secretion of hormones. However, the effect of IH on the production of adrenal cortical steroid hormones is still unclear. The aim of present study was to explore the mechanism involved in the effect of IH on the production of corticosterone by rat ZFR cells. Male rats were exposed at 12% O and 88% N (8 hours per day) for 1, 2, or 4 days. The ZFR cells were incubated at 37 °C for 1 hour with or without ACTH, 8-Br-cAMP, calcium ion channel blockers, or steroidogenic precursors. The concentration of plasma corticosterone was increased time-dependently by administration of IH hypoxia. The basal levels of corticosterone production in cells were higher in the IH groups than in normoxic group. IH resulted in a time-dependent increase of corticosterone production in response to ACTH, 8-Br-cAMP, progesterone and deoxycorticosterone. The production of pregnenolone in response to 25-OH-C and that of progesterone in response to pregnenolone in ZFR cells were enhanced by 4-day IH. These results suggest that IH in rats increases the secretion of corticosterone via a mechanism at least in part associated with the activation of cAMP pathway and steroidogenic enzymes.

摘要

缺氧或间歇性缺氧（IH）已知会改变激素的合成和分泌。然而，IH 对肾上腺皮质类固醇激素产生的影响尚不清楚。本研究的目的是探讨 IH 对大鼠 ZFR 细胞产生皮质酮的影响的机制。雄性大鼠每天暴露于 12% O 和 88% N 下 8 小时，持续 1、2 或 4 天。将 ZFR 细胞在 37°C 下孵育 1 小时，有或没有 ACTH、8-Br-cAMP、钙离子通道阻滞剂或甾体生成前体。通过给予 IH 缺氧，血浆皮质酮的浓度随时间呈时间依赖性增加。IH 组细胞中皮质酮产生的基础水平高于常氧组。IH 导致 ACTH、8-Br-cAMP、孕酮和脱氧皮质酮刺激的皮质酮产生呈时间依赖性增加。25-OH-C 刺激的 pregnenolone 产生和 pregnenolone 刺激的孕酮产生在 ZFR 细胞中分别增加 4 天 IH。这些结果表明，IH 在大鼠中通过至少部分与 cAMP 途径和甾体生成酶激活相关的机制增加皮质酮的分泌。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1eb6/5567345/4fbabddb8422/41598_2017_7054_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1eb6/5567345/d1781acde0bd/41598_2017_7054_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1eb6/5567345/75c863d42af4/41598_2017_7054_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1eb6/5567345/936743a12f85/41598_2017_7054_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1eb6/5567345/4cf7e06c8c79/41598_2017_7054_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1eb6/5567345/d5fc78a0f4c8/41598_2017_7054_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1eb6/5567345/11fe5bb49f70/41598_2017_7054_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1eb6/5567345/4114b9b0d47b/41598_2017_7054_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1eb6/5567345/ea5065deb08f/41598_2017_7054_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1eb6/5567345/4fbabddb8422/41598_2017_7054_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1eb6/5567345/d1781acde0bd/41598_2017_7054_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1eb6/5567345/75c863d42af4/41598_2017_7054_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1eb6/5567345/936743a12f85/41598_2017_7054_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1eb6/5567345/4cf7e06c8c79/41598_2017_7054_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1eb6/5567345/d5fc78a0f4c8/41598_2017_7054_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1eb6/5567345/11fe5bb49f70/41598_2017_7054_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1eb6/5567345/4114b9b0d47b/41598_2017_7054_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1eb6/5567345/ea5065deb08f/41598_2017_7054_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1eb6/5567345/4fbabddb8422/41598_2017_7054_Fig9_HTML.jpg

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