Feinberg G, Stokes T C
Int Arch Allergy Appl Immunol. 1987;82(3-4):537-8. doi: 10.1159/000234272.
In an animal model, topical application of levocabastine to the eye inhibits the inflammatory conjunctival response to topically applied histamine. This is so even at one-fourth the concentration at which levocabastine is normally dispensed. Total blocking of histamine response continues for 24 h and is then irregularly observable for an additional 72 h. Levocabastine may be absorbed through the conjunctiva to give systemically transmitted protection to the contralateral eye. Levocabastine is a potent competitor against histamine for conjunctival H1 receptors and should prove a useful, possibly long-acting drug for the reversal of inflammatory conjunctivitis and inhibition of its recurrence.
在动物模型中，将左卡巴斯汀局部应用于眼部可抑制结膜对局部应用组胺的炎症反应。即使在左卡巴斯汀通常给药浓度的四分之一时，也是如此。组胺反应的完全阻断持续24小时，然后在另外72小时内可不规则观察到。左卡巴斯汀可能通过结膜吸收，从而为对侧眼提供全身传递的保护。左卡巴斯汀是组胺与结膜H1受体的有力竞争者，应该证明是一种有用的、可能长效的药物，可用于逆转炎症性结膜炎并抑制其复发。
