肿瘤坏死因子受体1（TNFR1）与年龄、性别及基线肾功能状态相关的肾功能结局的关联：来自心灵研究的数据
Associations of TNFR1 with kidney function outcomes by age, gender, and baseline kidney function status: Data from the Heart and Soul Study.
作者信息
Park Meyeon, Maristany Daniela, Huang Debbie, Shlipak Michael G, Whooley Mary
机构信息
Division of Nephrology, University of California, San Francisco, San Francisco, CA, USA.
Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, USA.
出版信息
Data Brief. 2017 Jul 26;14:366-370. doi: 10.1016/j.dib.2017.07.048. eCollection 2017 Oct.
Tumor necrosis factor receptor type 1 (TNFR1) is associated with kidney disease and mortality risk in various populations [1], [2]. We evaluated associations of TNFR1 with mortality and mediators of this relationship in doi: 10.1016/j.atherosclerosis.2017.05.021. Whether or not these associations are influenced by age, gender, or baseline kidney function are not known. We evaluated associations of TNFR1 levels with measures of kidney function stratifying by these variables. Our outcomes included estimated glomerular filtration rate (eGFR) < 60 ml/min/1.73 m, albumin to creatinine ratio (ACR) >30 mg/g, and rapid kidney function loss, defined as a change in eGFR of greater than 3% per year.
1型肿瘤坏死因子受体（TNFR1）与不同人群的肾脏疾病及死亡风险相关[1,2]。我们评估了TNFR1与死亡率及这种关系的介导因素之间的关联（doi: 10.1016/j.atherosclerosis.2017.05.021）。目前尚不清楚这些关联是否受年龄、性别或基线肾功能的影响。我们评估了按这些变量分层的TNFR1水平与肾功能指标之间的关联。我们的研究结果包括估计肾小球滤过率（eGFR）<60 ml/min/1.73 m²、白蛋白与肌酐比值（ACR）>30 mg/g，以及快速肾功能丧失，定义为eGFR每年变化大于3%。
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