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可溶性肿瘤坏死因子受体的潜在生物学和临床意义。

The potential biological and clinical significance of the soluble tumor necrosis factor receptors.

作者信息

Aderka D

机构信息

Sackler Faculty of Medicine, Tel Aviv University, Dept of Oncology, Tel-Aviv Medical Center, Israel.

出版信息

Cytokine Growth Factor Rev. 1996 Oct;7(3):231-40. doi: 10.1016/s1359-6101(96)00026-3.

DOI:10.1016/s1359-6101(96)00026-3
PMID:8971478
Abstract

The role of TNF receptors (TNF-Rs) is not limited to signal transduction but includes extracellular regulatory functions affecting systemic TNF bioavailability. This review summarizes the regulation of TNF-R shedding and its kinetics, the complex interaction between the soluble receptors and their ligand in vitro and in vivo, and the potential diagnostic, prognostic and therapeutic value of the soluble receptors in malignant, inflammatory, infectious and autoimmune disorders.

摘要

肿瘤坏死因子受体（TNF-Rs）的作用不仅限于信号转导，还包括影响全身TNF生物利用度的细胞外调节功能。本综述总结了TNF-R脱落的调节及其动力学、可溶性受体与其配体在体外和体内的复杂相互作用，以及可溶性受体在恶性、炎症、感染和自身免疫性疾病中的潜在诊断、预后和治疗价值。

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