Ratnasooriya W D, Wadsworth R M
Int J Fertil. 1987 Mar-Apr;32(2):152-6.
Rods 2 mm in diameter and 8 mm long containing 25% or 50% indomethacin were implanted adjacent to each epididymis in rats of proven fertility. During the first 4 weeks after operation, fertility was reduced, but returned to normal at 5 to 10 weeks. The time of onset and duration of the effect were variable. Libido, ejaculation, and sperm motility were unimpaired. Drug-free Silastic rods had no effect on fertility. The results provide indirect evidence that prostaglandins have a functional role in the reproductive system of the male rat.
将直径2毫米、长8毫米且含有25%或50%吲哚美辛的棒状物植入经证实具有生育能力的大鼠双侧附睾附近。在术后的前4周，生育能力下降，但在5至10周时恢复正常。这种效应的起效时间和持续时间各不相同。性欲、射精及精子活力未受损害。不含药物的硅橡胶棒对生育能力没有影响。这些结果提供了间接证据，表明前列腺素在雄性大鼠的生殖系统中具有功能性作用。
