Rosenbaum C M, Ernst L, Engel O, Dahlem R, Fisch M, Kluth L A
Klinik und Poliklinik für Urologie, Universitätsklinikum Hamburg-Eppendorf, Martinistraße 52, 20246, Hamburg, Deutschland.
Urologe A. 2017 Oct;56(10):1274-1281. doi: 10.1007/s00120-017-0475-4.
Urethral strictures can occur on the basis of trauma, infections, iatrogenic-induced or idiopathic and have a great influence on the patient's quality of life. The current prevalence rate of male urethral strictures is 0.6% in industrialized western countries. The favored form of treatment has experienced a transition from less invasive interventions, such as urethrotomy or urethral dilatation, to more complex open surgical reconstruction. Excision and primary end-to-end anastomosis and buccal mucosa graft urethroplasty are the most frequently applied interventions with success rates of more than 80%. Risk factors for stricture recurrence after urethroplasty are penile stricture location, the length of the stricture (>4 cm) and prior repeated endoscopic therapy attempts. Radiation-induced urethral strictures also have a worse outcome. There are various therapy options in the case of stricture recurrence after a failed urethroplasty. In the case of short stricture recurrences, direct vision urethrotomy shows success rates of approximately 60%. In cases of longer or more complex stricture recurrences, redo urethroplasty should be the therapy of choice. Success rates are higher than after urethrotomy and almost comparable to those of primary urethroplasty. Patient satisfaction after redo urethroplasty is high. Primary buccal mucosa grafting involves a certain rate of oral morbidity. In cases of a redo urethroplasty with repeated buccal mucosa grafting, oral complications are only slightly higher.
尿道狭窄可因创伤、感染、医源性因素或特发性因素而发生,对患者的生活质量有很大影响。在西方工业化国家,男性尿道狭窄的当前患病率为0.6%。治疗的首选形式已从侵入性较小的干预措施,如尿道切开术或尿道扩张术,转变为更复杂的开放性手术重建。切除并一期端端吻合术和颊黏膜移植尿道成形术是最常应用的干预措施,成功率超过80%。尿道成形术后狭窄复发的危险因素包括阴茎狭窄部位、狭窄长度(>4 cm)和既往反复的内镜治疗尝试。放射诱导的尿道狭窄预后也较差。尿道成形术失败后狭窄复发时有多种治疗选择。对于短段狭窄复发,直视下尿道切开术的成功率约为60%。对于较长或较复杂的狭窄复发,再次尿道成形术应是首选治疗方法。其成功率高于尿道切开术,几乎与一期尿道成形术相当。再次尿道成形术后患者满意度较高。一期颊黏膜移植会有一定的口腔发病率。在重复颊黏膜移植的再次尿道成形术中,口腔并发症仅略高。