Temur Muzaffer, Özün Özbay Pelin, Aksun Saliha, Yilmaz Özgür, Çift Tayfur, Üstünel Sibel, Calan Mehmet
Department of Obstetrics and Gynecology, Bursa Yüksek İhtisas Education and Research Hospital, 16290, Bursa, Turkey.
Department of Obstetrics and Gynecology, Aydın Private Liva Hospital, 09010, Aydın, Turkey.
Arch Gynecol Obstet. 2017 Oct;296(4):841-846. doi: 10.1007/s00404-017-4493-7. Epub 2017 Aug 22.
This study was conducted to compare serum xenopsin-related peptide-1 (XP-1) levels in women with polycystic ovary syndrome (PCOS) and in healthy women and to determine the role of XP-1 levels in PCOS.
Forty patients with PCOS and 38 healthy women were included in the study and matched with age and body mass index. Fasting blood glucose, insulin, high sensitivity C-reactive protein (hs-CRP), XP-1 and total testosterone levels of all participants were measured.
Serum XP-1 levels significantly increased in women with PCOS compared to the control group (6.49 ± 1.57 vs 5.29 ± 1.45 ng/ml, p = 0.001). Serum insulin, hs-CRP, HOMA-IR, total testosterone levels and waist circumference were higher in women with PCOS than in control group. High XP-1 levels were associated with PCOS after adjustment for potential confounders. Receiver operating characteristic (ROC) curve analysis confirmed that the area under ROC curves was 0.703 (95% CI 0.588-0.818, p < 0.002) for XP-1 levels. The optimal cut-off value of XP-1 for detecting PCOS was ≥5.87 ng/ml.
Our results indicate that increased XP-1 levels were associated with PCOS after adjustment for potential confounders, which has been shown to be effective in the function of the insulin signaling pathway.
本研究旨在比较多囊卵巢综合征（PCOS）女性与健康女性血清中异种视蛋白相关肽-1（XP-1）水平，并确定XP-1水平在PCOS中的作用。
本研究纳入40例PCOS患者和38例健康女性，并根据年龄和体重指数进行匹配。测量所有参与者的空腹血糖、胰岛素、高敏C反应蛋白（hs-CRP）、XP-1和总睾酮水平。
与对照组相比，PCOS女性血清XP-1水平显著升高（6.49±1.57 vs 5.29±1.45 ng/ml，p = 0.001）。PCOS女性的血清胰岛素、hs-CRP、HOMA-IR、总睾酮水平和腰围均高于对照组。在对潜在混杂因素进行校正后，XP-1水平升高与PCOS相关。受试者工作特征（ROC）曲线分析证实，XP-1水平的ROC曲线下面积为0.703（95%CI 0.588 - 0.818，p < 0.002）。检测PCOS的XP-1最佳截断值为≥5.87 ng/ml。
我们的结果表明，在对潜在混杂因素进行校正后，XP-1水平升高与PCOS相关，这已被证明在胰岛素信号通路功能中有效。
