Scott-Sheldon Lori A J, Carey Kate B, Johnson Blair T, Carey Michael P
Centers for Behavioral and Preventive Medicine, The Miriam Hospital, CORO Building, Suite 309, 164 Summit Ave., Providence, RI, 02906, USA.
Department of Psychiatry and Human Behavior, Alpert School of Medicine, Brown University, Providence, RI, USA.
AIDS Behav. 2017 Nov;21(Suppl 2):126-143. doi: 10.1007/s10461-017-1886-3.
Alcohol use is often reported among people living with HIV/AIDS (PLWHA) and is associated with increased sexual risk and poor medication adherence. This meta-analysis evaluated the efficacy of behavioral interventions addressing alcohol use among PLWHA. Twenty-one studies (N = 8461 PLWHA) that evaluated an individual-level intervention addressing alcohol use alone or as part of a more comprehensive alcohol/HIV intervention, included a control condition, and were available through December 2016 were included. Independent raters coded study, sample, and intervention content. Weighted mean effect sizes, using random-effects models, were calculated. Results indicate that interventions reduced alcohol consumption, increased condom use, and improved medication adherence relative to controls (d s = 0.10-0.24). Plasma viral load was also reduced in intervention versus control participants (d = 0.14, 95% CI = 0.02, 0.26; k = 7). These findings show that behavioral interventions addressing alcohol use can successfully reduce alcohol consumption and also improve HIV-related outcomes among PLWHA.
在艾滋病毒/艾滋病感染者（PLWHA）中，饮酒现象屡见不鲜，且与性风险增加和药物依从性差有关。这项荟萃分析评估了针对PLWHA饮酒问题的行为干预措施的效果。纳入了21项研究（N = 8461名PLWHA），这些研究评估了单独针对饮酒问题的个体层面干预措施，或作为更全面的酒精/艾滋病毒干预措施的一部分，包括对照条件，且截至2016年12月可获取。独立评分者对研究、样本和干预内容进行编码。使用随机效应模型计算加权平均效应量。结果表明，与对照组相比，干预措施减少了酒精消费，增加了避孕套使用，并改善了药物依从性（d值 = 0.10 - 0.24）。与对照组参与者相比，干预组参与者的血浆病毒载量也有所降低（d = 0.14，95% CI = 0.02，0.26；k = 7）。这些发现表明，针对饮酒问题的行为干预措施可以成功减少酒精消费，并改善PLWHA中与艾滋病毒相关的结果。
