两名患有与阿尔茨海默病相关激越症状的患者接受极低剂量抗精神病药物治疗。
Very low-dose neuroleptic treatment in two patients with agitation associated with Alzheimer's disease.
作者信息
Risse S C, Lampe T H, Cubberley L
出版信息
J Clin Psychiatry. 1987 May;48(5):207-8.
PMID:2883174
Abstract
Two agitated patients with Alzheimer's disease who either failed to respond or worsened with conventional low-dose neuroleptic and other pharmacologic treatment are described. Both patients demonstrated sustained improvement with very low-dose neuroleptics, one with haloperidol 0.125 mg and the other with thioridazine 5 mg. Clinical, pharmacokinetic, and pharmacodynamic factors that may have accounted for this response are discussed.
摘要
描述了两名患有阿尔茨海默病且躁动不安的患者，他们对传统低剂量抗精神病药物及其他药物治疗无反应或病情恶化。两名患者使用极低剂量抗精神病药物后均持续改善，一名使用0.125毫克氟哌啶醇，另一名使用5毫克甲硫达嗪。讨论了可能导致这种反应的临床、药代动力学和药效学因素。
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