偏头痛病理生理学中的钾通道：偏头痛的新型治疗靶点。
The K channel in migraine pathophysiology: a novel therapeutic target for migraine.
作者信息
Al-Karagholi Mohammad Al-Mahdi, Hansen Jakob Møller, Severinsen Johanne, Jansen-Olesen Inger, Ashina Messoud
机构信息
Danish Headache Center, Department of Neurology, Rigshospitalet Glostrup, Faculty of Health and Medical Sciences, University of Copenhagen, Nordre Ringvej 57, DK-2600, Copenhagen, Denmark.
Danish Headache Center, Department of Neurology, Glostrup Research Park, Rigshospitalet Glostrup, Copenhagen, Denmark.
出版信息
J Headache Pain. 2017 Aug 23;18(1):90. doi: 10.1186/s10194-017-0800-8.
BACKGROUND
To review the distribution and function of K channels, describe the use of K channels openers in clinical trials and make the case that these channels may play a role in headache and migraine.
DISCUSSION
K channels are widely present in the trigeminovascular system and play an important role in the regulation of tone in cerebral and meningeal arteries. Clinical trials using synthetic K channel openers report headache as a prevalent-side effect in non-migraine sufferers, indicating that K channel opening may cause headache, possibly due to vascular mechanisms. Whether K channel openers can provoke migraine in migraine sufferers is not known.
CONCLUSION
We suggest that K channels may play an important role in migraine pathogenesis and could be a potential novel therapeutic anti-migraine target.
背景
回顾钾通道的分布和功能，描述钾通道开放剂在临床试验中的应用，并论证这些通道可能在头痛和偏头痛中发挥作用。
讨论
钾通道广泛存在于三叉神经血管系统中，在调节脑动脉和脑膜动脉张力方面发挥重要作用。使用合成钾通道开放剂的临床试验报告称，头痛是非偏头痛患者中普遍存在的副作用，这表明钾通道开放可能会引发头痛，可能是由于血管机制。目前尚不清楚钾通道开放剂是否会诱发偏头痛患者的偏头痛发作。
结论
我们认为钾通道可能在偏头痛发病机制中起重要作用，并且可能是一种潜在的新型抗偏头痛治疗靶点。
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