偏头痛病理生理学的最新见解：三磷酸腺苷敏感性钾通道。
Latest Insights into the Pathophysiology of Migraine: the ATP-Sensitive Potassium Channels.
机构信息
Danish Headache Center, Department of Neurology, Rigshospitalet Glostrup, Faculty of Health and Medical Sciences, University of Copenhagen, Valdemar Hansen Vej 5, Glostrup, DK-2600, Copenhagen, Denmark.
Danish Headache Knowledge Center, Rigshospitalet - Glostrup, Valdemar Hansens Vej 5, DK-2600, Glostrup, Denmark.
出版信息
Curr Pain Headache Rep. 2020 Dec 3;24(12):77. doi: 10.1007/s11916-020-00911-6.
PURPOSE OF REVIEW
Migraine remains a challenging condition to treat, thus highlighting the need for a better understanding of its molecular mechanisms. This review intends to unravel a new emerging target in migraine pathophysiology, the adenosine 5'-triphosphate-sensitive K (K) channel.
RECENT FINDINGS
K channel is a common denominator in the cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) mediated intracellular cascades, both of which are involved in migraine. Intravenous infusion of K channel opener, levcromakalim, provoked migraine attack associated with dilation of extracerebral arteries in all persons with migraine. Preclinical and clinical studies implicate K channels in migraine initiation. K channel is a novel therapeutic target for the acute and preventive treatment of migraine. Future studies are warranted to provide a better understanding of the role of K channel subgroups in migraine.
目的综述
偏头痛仍然是一种具有挑战性的治疗疾病，因此需要更好地了解其分子机制。本综述旨在揭示偏头痛病理生理学中的一个新的新兴靶点，即三磷酸腺苷敏感性钾 (K) 通道。
最新发现
K 通道是环磷酸腺苷 (cAMP) 和环鸟苷酸 (cGMP) 介导的细胞内级联反应中的共同因素，两者均与偏头痛有关。静脉输注 K 通道 opener 利马卡林可引起偏头痛发作，并伴有偏头痛患者的颅外动脉扩张。临床前和临床研究表明 K 通道参与偏头痛的发生。K 通道是治疗偏头痛急性发作和预防偏头痛的新的治疗靶点。有必要进行进一步的研究以更好地了解 K 通道亚群在偏头痛中的作用。
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