State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University , Chengdu, Sichuan Province 610041, P. R. China.
ACS Appl Mater Interfaces. 2017 Sep 13;9(36):30437-30447. doi: 10.1021/acsami.7b09176. Epub 2017 Aug 31.
The structure of materials is known to play an important role in material function. Nowadays, flowerlike structures have gained attention for studies not only in analytical chemistry, but also in biomaterial design. In this study, flowerlike structures were applied in bone regeneration in the form of calcium phosphate microflowers. The material was synthesized by a simple and environmentally friendly method. We characterized the structure and properties of the microflower using various methods. Cytotoxicity and osteogenesis-related gene regulations of the microflower were investigated in vitro. Cell uptake was observed by immunofluorescence. Rat calvarial critical-size defect models were successfully established to further confirm the enhanced bone regeneration ability of this material. We expect that this novel study will be of practical importance for the extended application of flowerlike materials and will provide new insights into the optimization of the morphology of calcium phosphate materials.
众所周知，材料的结构在材料功能中起着重要作用。如今，不仅在分析化学领域，而且在生物材料设计领域，人们都开始关注花状结构。在这项研究中，我们以磷酸钙微花的形式将花状结构应用于骨再生。该材料是通过一种简单且环保的方法合成的。我们使用各种方法对微花的结构和性能进行了表征。通过体外实验研究了微花的细胞毒性和与成骨相关的基因调控。通过免疫荧光观察细胞摄取。成功建立了大鼠颅骨临界尺寸缺损模型，以进一步证实该材料增强的骨再生能力。我们期望这项新的研究对于花状材料的广泛应用具有实际意义，并为优化磷酸钙材料的形态提供新的思路。
