Kowalczyk Dorota, Albrecht Łukasz
Institute of Organic Chemistry, Department of Chemistry, Lodz University of Technology, Zeromskiego 116, 90-924 Łódź, Poland.
Org Biomol Chem. 2017 Sep 13;15(35):7286-7289. doi: 10.1039/c7ob01570d.
A new, cis-selective, approach for the synthesis of bicyclic δ-lactones bearing a fused cyclohex-2-en-1-one moiety is described. The strategy utilizes a cascade reactivity of cyclic 1,3-diketones and 3-arylidenefuran-2(3H)-ones with the butenolide-ring-opening reaction enabling the construction of the δ-lactone framework. It benefits from broad scope, high enantioselectivity and excellent cis-diastereoselectivity.
描述了一种合成带有稠合环己-2-烯-1-酮部分的双环δ-内酯的新的顺式选择性方法。该策略利用环状1,3-二酮和3-亚芳基呋喃-2(3H)-酮的串联反应性以及丁烯内酯开环反应来构建δ-内酯骨架。它具有适用范围广、对映选择性高和出色的顺式非对映选择性的优点。
