Cooper B T, Barbezat G O
J Clin Gastroenterol. 1987 Apr;9(2):139-41. doi: 10.1097/00004836-198704000-00006.
The effect of the H2 receptor antagonists, cimetidine and ranitidine, on Barrett's esophagus was assessed in a retrospective study. There was no evidence of regression of Barrett's epithelium in the 22 patients treated for a mean of 13 months with 800-1,600 mg/day cimetidine, or in the 13 patients treated for a mean of 5.7 months with 300 mg/day ranitidine. Eight of 12 esophageal (Barrett's) ulcers healed on cimetidine therapy over a mean period of 8.7 months, and eight of nine esophageal ulcers healed on ranitidine therapy over a mean period of 3.5 months. We conclude that short-term treatment with H2 blockade does not cause regression of Barrett's esophagus, although such treatment can heal esophageal ulcers.
在一项回顾性研究中评估了H2受体拮抗剂西咪替丁和雷尼替丁对巴雷特食管的影响。接受平均13个月、每日800 - 1600毫克西咪替丁治疗的22例患者，以及接受平均5.7个月、每日300毫克雷尼替丁治疗的13例患者，均未发现巴雷特上皮有消退迹象。12例食管（巴雷特）溃疡患者中，8例在平均8.7个月的西咪替丁治疗后愈合，9例食管溃疡患者中，8例在平均3.5个月的雷尼替丁治疗后愈合。我们得出结论，H2受体阻滞剂的短期治疗虽可治愈食管溃疡，但不会使巴雷特食管消退。
