Hameeteman W, Tytgat G N
Am J Gastroenterol. 1986 Sep;81(9):764-6.
Three patients with a long-standing benign Barrett ulcer, resistant to treatment with high doses of either cimetidine or ranitidine, given for at least 3 months, were treated with 40 mg omeprazole daily for 9 wk. After 2 wk all symptoms had disappeared and at the end of treatment all three patients showed complete endoscopic ulcer healing. Patient compliance was excellent and no side effects were registered. We conclude that omeprazole is effective and safe in healing chronic resistant Barrett ulcers.
三名患有长期良性巴雷特溃疡的患者，对高剂量西咪替丁或雷尼替丁治疗（至少服用3个月）无效，每天服用40毫克奥美拉唑，持续9周。2周后所有症状消失，治疗结束时，所有三名患者的溃疡在内镜检查下均完全愈合。患者依从性良好，未出现副作用。我们得出结论，奥美拉唑在治疗慢性难治性巴雷特溃疡方面有效且安全。
