School of Engineering and Applied Sciences, National University of Mongolia , Ulaanbaatar 14201, Mongolia.
Mongolian University of Pharmaceutical Sciences , Ulaanbaatar 18130, Mongolia.
J Nat Prod. 2017 Sep 22;80(9):2416-2423. doi: 10.1021/acs.jnatprod.7b00142. Epub 2017 Aug 23.
Eight new flavonoid-based 3'-O-β-d-glucopyranosides (1-8) and three new galloyl glucosides (9, 11, 12), were isolated from the aerial parts of Saxifraga spinulosa, along with 25 known compounds. The structures of the new compounds were elucidated by spectroscopic methods. Most of the isolated compounds exhibited potent DPPH radical-scavenging activities. Further, their inhibitory activities were evaluated against Babesia bovis, Babesia bigemina, Babesia caballi, and Theileria equi, protozoan parasites that cause piroplasmosis in livestock. The results indicated that several of these compounds showed growth-inhibitory effects on such organisms that cause piroplasmosis.
从绵毛楼梯草的地上部分分离得到了 8 个新的基于黄酮的 3'-O-β-d-吡喃葡萄糖苷（1-8）和 3 个新的没食子酰葡萄糖苷（9、11、12），以及 25 个已知化合物。新化合物的结构通过光谱方法阐明。大多数分离得到的化合物表现出很强的 DPPH 自由基清除活性。此外，还评估了它们对引起家畜梨形虫病的巴贝斯虫属、双芽巴贝斯虫属、马巴贝斯虫属和泰勒虫属的抑制活性。结果表明，这些化合物中的一些对引起梨形虫病的生物体具有生长抑制作用。
