Zhang Zhe, Yin Jiefeng, Xu Qi, Shi Jianfeng
General Surgery Department, Tongde Hospital of Zhejiang Province, Hangzhou, China.
Department of Abdominal Medical Oncology, Zhejiang Cancer Hospital, Hangzhou, China.
J Clin Lab Anal. 2018 Oct;32(8):e22564. doi: 10.1002/jcla.22564. Epub 2018 May 7.
Xeroderma pigmentosum group G (XPG) plays an important role in maintaining the stability and integrity of genomic DNA. Previous studies demonstrate some XPG gene polymorphisms are associated with susceptibility to gastric cancer (GC).
The association between XPG rs2094258 polymorphism and GC risk was investigated first by a hospital-based case-control study involving 386 patients and 439 controls and then by a meta-analysis. The polymorphism was genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLR).
Xeroderma pigmentosum group G rs2094258 polymorphism was associated with an increased risk of GC in a Chinese population. The meta-analysis did not reveal any significant difference in the overall population. Subgroup analysis of geographic locations showed a significant association between the XPG gene rs2094258 polymorphism and GC risk in Southern China. Stratification analysis further indicated significant associations in hospital-based studies and studies using PCR-RFLR.
Xeroderma pigmentosum group G gene rs2094258 polymorphism may be associated with an increased risk of GC in Southern China. Nevertheless, the findings of this meta-analysis should be validated by well-designed large-scale case-control studies among other ethnicities.
着色性干皮病G组（XPG）在维持基因组DNA的稳定性和完整性方面发挥着重要作用。先前的研究表明，一些XPG基因多态性与胃癌（GC）易感性相关。
首先通过一项基于医院的病例对照研究（涉及386例患者和439例对照），然后通过荟萃分析，研究XPG rs2094258多态性与GC风险之间的关联。采用聚合酶链反应-限制性片段长度多态性（PCR-RFLR）对该多态性进行基因分型。
在中国人群中，着色性干皮病G组rs2094258多态性与GC风险增加相关。荟萃分析未显示总体人群中有任何显著差异。地理位置亚组分析显示，XPG基因rs2094258多态性与中国南方的GC风险之间存在显著关联。分层分析进一步表明，在基于医院的研究和使用PCR-RFLR的研究中存在显著关联。
着色性干皮病G组基因rs2094258多态性可能与中国南方GC风险增加相关。然而，这一荟萃分析的结果应通过在其他种族中精心设计的大规模病例对照研究进行验证。
