Harvard-MIT Program in Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
Department of Radiology, Harvard Medical School, Boston, Massachusetts, USA.
Muscle Nerve. 2018 Mar;57(3):423-429. doi: 10.1002/mus.25779. Epub 2017 Sep 30.
Muscle echo intensity has been shown to correlate with disease status in muscle disorders, including Duchenne muscular dystrophy (DMD). We report the effect of sonographer-applied load on measurements of muscle echo intensity.
Quadriceps ultrasound scans were performed on 22 healthy boys and 16 boys with DMD between the ages of 2.2 and 15.3 years. Transducer contact force was increased linearly from 1.5 to 10 N, and echo intensity was measured throughout.
Echo intensity increased linearly with strain at a rate of 42 (95% confidence interval [CI]: 21-63) and 74 (95% CI: 49-98) in the healthy and DMD populations, respectively. Echo intensity reliability was moderate at low strain (intraclass correlation coefficient [ICC] = 0.82) and was improved at high strain (ICC = 0.92).
Sonographer-applied load introduces error in measurements of echo intensity, but it can be minimized by measuring echo intensity at near-maximal levels of compression. Muscle Nerve 57: 423-429, 2018.
肌肉回声强度与肌肉疾病的疾病状态相关，包括杜氏肌营养不良症（DMD）。我们报告了超声医师施加的负荷对肌肉回声强度测量的影响。
对 22 名健康男孩和 16 名年龄在 2.2 至 15.3 岁之间的 DMD 男孩进行股四头肌超声扫描。线性增加换能器接触力从 1.5 至 10 N，并在整个过程中测量回声强度。
在健康人群和 DMD 人群中，回声强度分别以 42（95%置信区间 [CI]：21-63）和 74（95% CI：49-98）的速率随应变线性增加。在低应变时，回声强度的可靠性为中等（组内相关系数 [ICC] = 0.82），在高应变时得到改善（ICC = 0.92）。
超声医师施加的负荷会给回声强度的测量带来误差，但通过在接近最大压缩水平测量回声强度，可以将其最小化。肌肉神经 57: 423-429, 2018.
