Gao Lijuan, Chen Jiu, Gu Lihua, Shu Hao, Wang Zan, Liu Duan, Yan Yanna, Zhang Zhijun
Department of Neurology, Affiliated Zhongda Hospital, School of Medicine, Southeast University, Nanjing, China.
Department of Psychology, Xinxiang Medical University, Xinxiang, China.
Front Aging Neurosci. 2018 Aug 21;10:256. doi: 10.3389/fnagi.2018.00256. eCollection 2018.
The apolipoprotein E epsilon4 ( ε4) allele and female gender may be important risk factors for the development of Alzheimer's disease and amnestic mild cognitive impairment (aMCI). Novelty mismatch negativity (MMN) represents the pre-attentive index of deviance detection and P3a represents the attention orienting response. Furthermore, MMN and P3a components have been reported to be potential markers in aMCI. Therefore, this study will investigate the effects of gender and on auditory novelty MMN and P3a and their relationship to neuropsychological performance in aMCI. Thirty nine aMCI subjects and 44 controls underwent neuropsychological assessment and genotyping. Novelty MMN and P3a components were investigated during an auditory novelty oddball task. Firstly, novelty MMN latency was significantly shorter in aMCI than in healthy control (HC) group. Secondly, novelty MMN latency was negatively correlated with episodic memory in aMCI, but not in HC. Novelty P3a latency was negatively correlated with information processing speed in all subjects. For gender effect, novelty MMN latency was shorter in aMCI females than in HC females. Moreover, novelty P3a amplitudes were lower in males than in females in both aMCI and HC. For the effect of status, novelty MMN latency was shorter in aMCI ε4- than HC ε4-. aMCI presents altered pre-attentive processing indexed by novelty MMN components. Furthermore, there may be a compensatory mechanism on the impaired processing in aMCI. It further suggests that aMCI female and ε4- recruited the compensatory mechanism.
载脂蛋白E ε4等位基因和女性性别可能是阿尔茨海默病和遗忘型轻度认知障碍（aMCI）发生的重要危险因素。新奇失配负波（MMN）代表偏差检测的前注意指标，P3a代表注意定向反应。此外，MMN和P3a成分已被报道为aMCI的潜在标志物。因此，本研究将调查性别和[此处原文缺失相关内容]对听觉新奇MMN和P3a的影响及其与aMCI神经心理表现的关系。39名aMCI受试者和44名对照者接受了神经心理评估和基因分型。在听觉新奇oddball任务中研究了新奇MMN和P3a成分。首先，aMCI组的新奇MMN潜伏期显著短于健康对照组（HC）。其次，aMCI组的新奇MMN潜伏期与情景记忆呈负相关，而HC组则无此相关性。新奇P3a潜伏期在所有受试者中与信息处理速度呈负相关。对于性别效应，aMCI女性的新奇MMN潜伏期短于HC女性。此外，在aMCI组和HC组中，男性的新奇P3a波幅均低于女性。对于[此处原文缺失相关内容]状态的影响，aMCI ε4-组的新奇MMN潜伏期短于HC ε4-组。aMCI表现出由新奇MMN成分索引的前注意加工改变。此外，aMCI受损加工过程中可能存在一种代偿机制。这进一步表明aMCI女性和ε4-组启动了代偿机制。
