Regional Center for HIV Care and Coordination, Toulouse University Hospital, Toulouse, France.
INSERM UMR 1027, Toulouse 3 University, Toulouse, France.
HIV Med. 2018 Mar;19(3):238-242. doi: 10.1111/hiv.12545. Epub 2017 Aug 18.
The aim of the study was to determine whether there is a relationship between social deprivation and time of HIV diagnosis in France.
Prospectively collected data from a multicentre database were used in the study. Patients with a first HIV diagnosis between 1 January 2014 and 31 December 2015 were selected from the database. Deprivation was measured using the European Deprivation Index (EDI), which is an ecological index constructed from the address of residence and based on the smallest geographical census unit, in which individuals are classified so as to be comparable with national quintiles. Time of diagnosis was classified as being at an early, intermediate, late, or advanced stage of disease. Age, gender, distance from home to HIV centre, most probable route of infection, and hepatitis B or C coinfection were considered in the analysis. Because of a strong interaction between gender and most probable route of infection, we constructed a 'population' variable: men who have sex with men (MSM), heterosexual men and women.
Of 1421 newly diagnosed patients, 44% were diagnosed either late or at an advanced stage of disease, and 46.3% were in the highest deprivation quintile. Using multivariate logistic regression, 'population' [odds ratio (OR) 0.62 (95% confidence interval (CI) 0.48-0.78) for MSM compared with women] and age [OR 1.39 (95% CI 1.07-1.80), 1.72 (1.32-2.23) and 1.86 (1.40-2.47) for the second, third and fourth quartiles, respectively, compared with the first quartile] were found to be related to late diagnosis. EDI level was not related to late HIV diagnosis.
'Population' seems to be more relevant than EDI to define evidence-based interventions to limit late diagnosis.
本研究旨在确定法国的社会剥夺与艾滋病毒诊断时间之间是否存在关联。
本研究使用来自一个多中心数据库的前瞻性收集数据。从数据库中选择了 2014 年 1 月 1 日至 2015 年 12 月 31 日期间首次诊断为艾滋病毒的患者。使用欧洲剥夺指数(EDI)衡量剥夺程度,这是一种基于居住地址构建的生态指数,基于最小的地理普查单位,对个人进行分类,使其与国家五分位数相比较。诊断时间分为疾病的早期、中期、晚期或晚期。在分析中考虑了年龄、性别、距艾滋病毒中心的距离、最可能的感染途径以及乙型肝炎或丙型肝炎合并感染。由于性别和最可能的感染途径之间存在很强的相互作用,我们构建了一个“人群”变量:男男性行为者(MSM)、异性恋男性和女性。
在 1421 名新诊断的患者中,44%被诊断为晚期或处于疾病晚期,46.3%处于最高剥夺五分位数。使用多变量逻辑回归,“人群”[与女性相比,男男性行为者的比值比(OR)为 0.62(95%置信区间(CI)为 0.48-0.78)]和年龄[OR 1.39(95%CI 1.07-1.80),1.72(1.32-2.23)和 1.86(1.40-2.47),分别与第一四分位相比,第二、第三和第四四分位]与晚期诊断相关。EDI 水平与晚期艾滋病毒诊断无关。
“人群”似乎比 EDI 更能确定基于证据的干预措施,以限制晚期诊断。