Omori Y, Takahashi A, Ohno Y, Ishiwata H, Tanimura A
Arch Toxicol Suppl. 1979(2):349-54. doi: 10.1007/978-3-642-67265-1_35.
Aminopyrine interacted with sodium nitrite in the stomachs of rats and guinea pigs forming dimethylnitrosamine, which affected the hepatic microsomal drug metabolism and certain hepatic enzyme activities. Sex and species differences in changes in the enzyme activities were observed after single or simultaneous administration of aminopyrine and sodium nitrite. A protective effect on dimethylnitrosamine formation with ascorbic acid and alpha-tocopherol was observed. The in vivo formation of dimethylnitrosamine by several antibiotics and an antihistaminic drug with tertiary amino group was also examined.
氨基比林在大鼠和豚鼠胃中与亚硝酸钠相互作用形成二甲基亚硝胺，这影响了肝微粒体药物代谢及某些肝酶活性。在单次或同时给予氨基比林和亚硝酸钠后，观察到了酶活性变化中的性别和物种差异。观察到抗坏血酸和α-生育酚对二甲基亚硝胺形成具有保护作用。还研究了几种抗生素和一种带有叔氨基的抗组胺药在体内形成二甲基亚硝胺的情况。
