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Studies on the metabolism of dimethylnitrosamine in the rat I. Effect of dose, route of administration and sex.

作者信息

Phillips J C, Lake B G, Heading C E, Gangolli S D, Lloyd A G

出版信息

Food Cosmet Toxicol. 1975 Apr;13(2):203-9. doi: 10.1016/s0015-6264(75)80005-8.

DOI:10.1016/s0015-6264(75)80005-8
PMID:1132850
Abstract
摘要

相似文献

1
Studies on the metabolism of dimethylnitrosamine in the rat I. Effect of dose, route of administration and sex.大鼠体内二甲基亚硝胺代谢的研究I.剂量、给药途径和性别的影响
Food Cosmet Toxicol. 1975 Apr;13(2):203-9. doi: 10.1016/s0015-6264(75)80005-8.
2
The absorption and metabolism in rats of small oral doses of dimethylnitrosamine. Implication for the possible hazard of dimethylnitrosamine in human food.大鼠对小剂量口服二甲基亚硝胺的吸收与代谢。对二甲基亚硝胺在人类食物中可能存在的危害的启示。
Biochem J. 1977 Jun 15;164(3):497-500. doi: 10.1042/bj1640497.
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Intestinal metabolism of nitrosamines. 1. Transport and metabolism of six nitrosamines in isolated perfused rat small intestinal segments.亚硝胺的肠道代谢。1. 六种亚硝胺在离体灌注大鼠小肠段中的转运与代谢。
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Drug-nitrite interactions: species and sex differences in the formation of dimethylnitrosamine and its effects on the hepatic enzyme activities.药物与亚硝酸盐的相互作用：二甲基亚硝胺形成过程中的物种和性别差异及其对肝酶活性的影响。
Arch Toxicol Suppl. 1979(2):349-54. doi: 10.1007/978-3-642-67265-1_35.
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The distribution of [14C]dimethylnitrosamine in mice. Autoradiographic studies in mice with inhibited and noninhibited dimethylnitrosamine metabolism and a comparison with the distribution of [14C]formaldehyde.
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6
Mechanism of dimethylnitrosamine metabolism and activation in rats.大鼠体内二甲基亚硝胺的代谢及活化机制
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Studies on nitrosamine metabolism. I. Subcellular distribution of radioactivity in tumor-susceptible tissues of RFM mice following administration of [14C]dimethylnitrosamine.
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Studies on the metabolism of dimethylnitrosamine in the rat. II. The effects of phenobarbitone and 20-methylcholanthrene on the in vitro and in vivo metabolism and acute toxicity of dimethylnitrosamine in young and mature rats.
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Selective induction of intestinal tumors in rats by methyl(acetoxymethyl)nitrosamine, an ester of the presumed reactive metabolite of dimethylnitrosamine.
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Methylation of DNA in rat liver and intestine by dimethylnitrosamine and N-methylnitrosourea.
Chem Biol Interact. 1977 Feb;16(2):135-43. doi: 10.1016/0009-2797(77)90123-5.

引用本文的文献

1
N-nitrosamines in the stomach with special reference to in vitro formation, and kinetics after intragastric or intravenous administration in rats.胃中的N-亚硝胺，特别提及体外形成以及大鼠经胃内或静脉给药后的动力学
Gastroenterol Jpn. 1990 Aug;25(4):417-24. doi: 10.1007/BF02779329.