Epigenetics of Stem Cells, Department of Developmental and Stem Cell Biology, Institut Pasteur, CNRS UMR3738, Paris, France.
FEBS Lett. 2018 Mar;592(6):852-877. doi: 10.1002/1873-3468.12826. Epub 2017 Sep 15.
Estrogen-related receptor b (Esrrb) is part of a family of three orphan nuclear receptors with broad expression profiles and a generic function in regulating energy metabolism in mammals. However, Esrrb performs specific functions during early mouse development, in pluripotent and multipotent populations of the embryo as well as in primordial germ cells. Moreover, Esrrb also impinges upon the control of self-renewal in embryo-derived stem cells and enhances reprogramming. Here, we review the function of Esrrb with special emphasis on its role in pluripotency. Esrrb activity at crucial regulatory elements of the pluripotency network, coupled with its role as a mitotic bookmarking factor and the ability to reset cellular metabolism, might explain its potent functions in ensuring the stability of pluripotency and driving the late stages of reprogramming. Hence, we argue that Esrrb represents a key addition to the pantheon of transcription factors sustaining pluripotent stem cell identity in mice. Understanding the mechanisms governing the interplay between different estrogen-related receptors (ERRs) and their specificity of action may clarify the role these factors play during preimplantation development and in pluripotent cells in both mouse and humans.
雌激素相关受体 b (Esrrb) 是具有广泛表达谱的三个孤儿核受体家族的一部分，其在哺乳动物中具有调节能量代谢的通用功能。然而，Esrrb 在早期小鼠发育、胚胎多能和多潜能群体以及原始生殖细胞中发挥特定功能。此外，Esrrb 还影响胚胎衍生干细胞的自我更新控制，并增强重编程。在这里，我们将特别强调 Esrrb 在多能性中的作用，来回顾 Esrrb 的功能。Esrrb 在多能性网络的关键调节元件上的活性，加上其作为有丝分裂书签因子的作用以及重置细胞代谢的能力，可能解释了其在确保多能性稳定性和推动重编程后期阶段的强大功能。因此，我们认为 Esrrb 是维持小鼠多能干细胞特性的转录因子群中的一个关键补充。了解不同雌激素相关受体 (ERRs) 之间相互作用的机制及其作用的特异性，可能阐明这些因子在植入前发育和小鼠及人类多能细胞中所起的作用。
