Ferraccioli G, Gremese E
Institute of Rheumatology, School of Medicine, Catholic University of the Sacred Heart, Rome, Italy.
Clin Exp Immunol. 2017 Dec;190(3):291-292. doi: 10.1111/cei.13039. Epub 2017 Sep 28.
Analysis of B cell activating factor (BAFF) receptors before and after B cell depletion therapy (BCDT) might offer a clue to the understanding of whether some B cell subsets may represent useful biomarkers of biological and clinical responses. Among the BAFF receptors in a cohort of rheumatoid arthritis (RA) patients, the AA have shown, by fluorescence activated cell sorter (FACS) analysis of median fluorescence intensity (MFI), that transmembrane activator and calcium-modulating cyclophilin ligand interactor (TACI) and B cell maturation antigen (BCMA) do not change, whereas the most important, BAFF receptor 3 (BR3), appears to be decreased before as well as after BCDT in all B cell subsets but not in plasmablasts, the most important subset, depleted by BCDT.
在B细胞清除疗法（BCDT）前后分析B细胞活化因子（BAFF）受体，可能为理解某些B细胞亚群是否可作为生物学和临床反应的有用生物标志物提供线索。在一组类风湿性关节炎（RA）患者的BAFF受体中，AA通过对中位荧光强度（MFI）进行荧光激活细胞分选仪（FACS）分析表明，跨膜激活剂和钙调节亲环素配体相互作用分子（TACI）以及B细胞成熟抗原（BCMA）没有变化，而最重要的BAFF受体3（BR3）在所有B细胞亚群中，无论在BCDT之前还是之后似乎都有所降低，但在浆母细胞中没有降低，浆母细胞是BCDT清除的最重要亚群。
