Peng Jian-Ping, Zheng Hang
Department of Urology, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan, People's Republic of China.
Medicine (Baltimore). 2017 Aug;96(34):e7898. doi: 10.1097/MD.0000000000007898.
We aimed to quantitatively assess the potential relationship between kidney stones and coronary heart disease or stroke.
A meta-analysis was conducted on eligibly studies published before 31 May 2016 in PubMed or Embase. The data were pooled, and the relationship was assessed by the random-effect model with inverse variance-weighted procedure. The results were expressed as relative risk (RR) with 95% confidence intervals (95%CI).
Eight studies of 11 cohorts (n = 11) were included in our analysis with 3,658,360 participants and 157,037 cases. We found that a history of kidney stones was associated with increased risk of coronary heart disease (CHD) (RR = 1.24; 95%CI: 1.14-1.36; I = 79.0%, n = 11); similar effect on myocardial infarction, a serious condition of CHD, was observed (RR = 1.24; 95%CI: 1.10-1.40; I = 80.4%, n = 8). We also found that a history of kidney stones may increase the risk of stroke (RR = 1.21, 95%CI: 1.06-1.38; I = 54.7%, n = 4). In subgroup analysis, the risk of coronary heart disease was higher in men (RR = 1.23, 95%CI: 1.02-1.49) while the risk for stroke was higher in women (RR = 1.12; 95%CI: 1.03-1.21). No obvious publications bias was detected (Egger test: P = .47).
Kidney stones are associated with increased risk of coronary heart disease and stroke, and the effect may differ by sex.
我们旨在定量评估肾结石与冠心病或中风之间的潜在关系。
对2016年5月31日前在PubMed或Embase上发表的符合条件的研究进行荟萃分析。汇总数据，并采用逆方差加权程序的随机效应模型评估这种关系。结果以相对风险（RR）及95%置信区间（95%CI）表示。
我们的分析纳入了11个队列中的8项研究（n = 11），参与者有3,658,360人，病例有157,037例。我们发现肾结石病史与冠心病（CHD）风险增加相关（RR = 1.24；95%CI：1.14 - 1.36；I² = 79.0%，n = 11）；对冠心病的严重情况心肌梗死也观察到类似影响（RR = 1.24；95%CI：1.10 - 1.40；I² = 80.4%，n = 8）。我们还发现肾结石病史可能增加中风风险（RR = 1.21，95%CI：1.06 - 1.38；I² = 54.7%，n = 4）。在亚组分析中，男性患冠心病的风险更高（RR = 1.23，95%CI：1.02 - 1.49），而女性患中风的风险更高（RR = 1.12；95%CI：1.03 - 1.21）。未检测到明显的发表偏倚（Egger检验：P = 0.47）。
肾结石与冠心病和中风风险增加相关，且这种影响可能因性别而异。
