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县级慢性淋巴细胞白血病发病率与住宅氡水平有关。

County level incidence rates of chronic lymphocytic leukemia are associated with residential radon levels.

机构信息

Department of Population Health, School of Medicine & Health Sciences, University of North Dakota, Grand Forks, ND 58202, USA.

Department of Geography & Geographic Information Science, University of North Dakota, College of Arts & Sciences, Grand Forks, ND 58202, USA.

出版信息

Future Oncol. 2017 Sep;13(21):1873-1881. doi: 10.2217/fon-2017-0165. Epub 2017 Aug 24.

DOI:10.2217/fon-2017-0165
PMID:28835109
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5618932/
Abstract

AIM

We previously reported that incidence rates for chronic lymphocytic leukemia (CLL) among US states are significantly correlated with levels of residential radon (RR). Because these correlations could be influenced by confounding and/or misclassification among large geographic units, we reinvestigated them using smaller geographic units that better reflect exposure and disease at the individual level.

METHODS

We examined the relationships between CLL and RR per county in 478 counties with publicly-available data.

RESULTS

After adjustment for ultraviolet radiation, a possible risk factor for CLL, county rates for CLL and RR were significantly correlated among males and females both together and separately (p < 0.0001).

CONCLUSION

CLL is significantly associated with RR at the county level.

摘要

目的

我们之前曾报道，美国各州慢性淋巴细胞白血病（CLL）的发病率与住宅氡（RR）水平显著相关。由于这些相关性可能受到大地理区域的混杂和/或分类错误的影响，我们使用更好地反映个体水平暴露和疾病的更小地理区域对其进行了重新研究。

方法

我们检查了 478 个有公开数据的县中每县的 CLL 和 RR 之间的关系。

结果

在调整紫外线辐射（CLL 的一个可能危险因素）后，男性和女性的 CLL 和 RR 的县率均存在显著相关性，无论是整体还是单独来看（p<0.0001）。

结论

CLL 与县一级的 RR 显著相关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d21/5618932/684edc408c81/fon-13-1873-g2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d21/5618932/755922b9bacd/fon-13-1873-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d21/5618932/684edc408c81/fon-13-1873-g2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d21/5618932/755922b9bacd/fon-13-1873-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d21/5618932/684edc408c81/fon-13-1873-g2.jpg

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