Lipinski J F, Cohen B M, Zubenko G S, Waternaux C M
Life Sci. 1987 May 18;40(20):1947-63. doi: 10.1016/0024-3205(87)90284-0.
Based on recent clinical and preclinical research, it is theorized that antimanic and antidepressant effects of clinically available drugs can be produced through their actions on alpha-1 adrenoreceptor-mediated neurotransmission in the central nervous system. The theory suggests that final effects on alpha-1 mediated neurotransmission may be produced not only by drugs which have direct effects on the alpha-1 receptor or its second messenger, but also by drugs having effects on neurotransmitter systems such as acetylcholine, GABA, and serotonin, among others, which modulate the activity of central norepinephrine neurons or, via feedback mechanisms, by drugs having effects on adrenergic receptors other than the alpha-1 receptor itself.
基于近期的临床和临床前研究，理论推测，临床上可用药物的抗躁狂和抗抑郁作用可能是通过其对中枢神经系统中α-1肾上腺素能受体介导的神经传递的作用而产生的。该理论表明，对α-1介导的神经传递的最终影响不仅可能由对α-1受体或其第二信使有直接作用的药物产生，还可能由对神经递质系统（如乙酰胆碱、γ-氨基丁酸和5-羟色胺等）有作用的药物产生，这些神经递质系统可调节中枢去甲肾上腺素能神经元的活性，或者通过反馈机制，由对α-1受体以外的肾上腺素能受体有作用的药物产生。
