爱泼斯坦-巴尔病毒潜伏膜蛋白1介导的致癌性。
Epstein-Barr Virus LMP1-Mediated Oncogenicity.
作者信息
Wang Liang Wei, Jiang Sizun, Gewurz Benjamin E
机构信息
Division of Infectious Disease, Brigham & Women's Hospital, Boston, Massachusetts.
Program in Virology, Harvard Medical School, Boston, Massachusetts.
出版信息
J Virol. 2017 Oct 13;91(21). doi: 10.1128/JVI.01718-16. Print 2017 Nov 1.
Abstract
Epstein-Barr virus latent membrane protein 1 (LMP1) is expressed in multiple human malignancies, including nasopharyngeal carcinoma and Hodgkin and immunosuppression-associated lymphomas. LMP1 mimics CD40 signaling to activate multiple growth and survival pathways, in particular, NF-κB. LMP1 has critical roles in Epstein-Barr virus (EBV)-driven B-cell transformation, and its expression causes fatal lymphoproliferative disease in immunosuppressed mice. Here, we review recent developments in studies of LMP1 signaling, LMP1-induced host dependency factors, mouse models of LMP1 lymphomagenesis, and anti-LMP1 immunotherapy approaches.
摘要
爱泼斯坦-巴尔病毒潜伏膜蛋白1（LMP1）在多种人类恶性肿瘤中表达，包括鼻咽癌、霍奇金淋巴瘤以及与免疫抑制相关的淋巴瘤。LMP1模拟CD40信号传导以激活多种生长和生存途径，特别是核因子κB（NF-κB）。LMP1在爱泼斯坦-巴尔病毒（EBV）驱动的B细胞转化中起关键作用，其表达在免疫抑制小鼠中会导致致命的淋巴增殖性疾病。在此，我们综述了LMP1信号传导、LMP1诱导的宿主依赖性因子、LMP1淋巴瘤发生的小鼠模型以及抗LMP1免疫治疗方法等研究的最新进展。
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