Biomaterials Innovation Research Center (BIRC), Division of Engineering in Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02139, USA.
Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
Sci Rep. 2017 Aug 23;7(1):9220. doi: 10.1038/s41598-017-04749-8.
Delivery of drugs with controlled temporal profiles is essential for wound treatment and regenerative medicine applications. For example, bacterial infection is a key challenge in the treatment of chronic and deep wounds. Current treatment strategies are based on systemic administration of high doses of antibiotics, which result in side effects and drug resistance. On-demand delivery of drugs with controlled temporal profile is highly desirable. Here, we have developed thermally controllable, antibiotic-releasing nanofibrous sheets. Poly(glycerol sebacate)- poly(caprolactone) (PGS-PCL) blends were electrospun to form elastic polymeric sheets with fiber diameters ranging from 350 to 1100 nm and substrates with a tensile modulus of approximately 4-8 MPa. A bioresorbable metallic heater was patterned directly on the nanofibrous substrate for applying thermal stimulation to release antibiotics on-demand. In vitro studies confirmed the platform's biocompatibility and biodegradability. The released antibiotics were potent against tested bacterial strains. These results may pave the path toward developing electronically controllable wound dressings that can deliver drugs with desired temporal patterns.
控制药物时变释放对于伤口治疗和再生医学应用至关重要。例如，细菌感染是慢性和深部伤口治疗的关键挑战。目前的治疗策略基于全身性给予大剂量抗生素，这会导致副作用和耐药性。因此，人们非常希望能够按需控制药物时变释放。在这里，我们开发了热控、释放抗生素的纳米纤维片。聚（癸二酸甘油酯）-聚（己内酯）（PGS-PCL）共混物通过静电纺丝形成具有 350 至 1100nm 纤维直径的弹性聚合物片材，以及拉伸模量约为 4-8MPa 的基底。将可生物降解的金属加热器直接图案化在纳米纤维基底上，以便对其进行热刺激，从而按需释放抗生素。体外研究证实了该平台的生物相容性和生物降解性。释放的抗生素对测试的细菌菌株具有很强的抗菌活性。这些结果可能为开发可电子控制的伤口敷料铺平道路，这些敷料可以按所需的时变模式输送药物。
