Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 580, 69120, Heidelberg, Germany.
Cancer Gene Therapy Group, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Breast Cancer Res Treat. 2017 Dec;166(3):897-902. doi: 10.1007/s10549-017-4468-1. Epub 2017 Aug 23.
Male breast cancer is associated with female breast cancer in families but whether male breast cancer clusters with other discordant cancers has not been studied. As concordant male breast cancers are utterly rare, discordant associations of male breast cancer with other cancers may reveal genetic and possible environmental risk factors contributing to male breast cancer susceptibility.
We calculated relative risks (RRs) for male breast cancer in families with discordant cancers, and conversely, for discordant cancers in families of male breast cancer patients, based on 15.7 million individuals in the Swedish Family-Cancer Database.
Among 1428 male breast cancer patients, 16.2% had a female relative diagnosed with breast cancer. Ovarian and female anal cancers showed the strongest associations with male breast cancer (p value < 0.0005). The other significant associations included colorectal, small intestinal, and thyroid cancers, cancer of unknown primary and non-Hodgkin lymphoma but these were each based on a single positive association with male breast cancer. The RRs for male breast cancer were increased in families in which multiple patients were diagnosed with diverse cancers, reaching an RR of 2.58 when three or more family members were affected.
The results suggest that male breast cancer shares susceptibility with a number of other cancers but confirmation is needed in other datasets.
男性乳腺癌与家族中的女性乳腺癌有关，但男性乳腺癌是否与其他不一致的癌症聚集尚未研究。由于一致的男性乳腺癌极为罕见，因此男性乳腺癌与其他癌症的不一致关联可能揭示了导致男性乳腺癌易感性的遗传和可能的环境风险因素。
我们基于瑞典家族癌症数据库中的 1570 万人，计算了具有不一致癌症的男性乳腺癌患者家庭的相对风险（RR），以及男性乳腺癌患者家庭中不一致癌症的 RR。
在 1428 名男性乳腺癌患者中，有 16.2%的女性亲属被诊断患有乳腺癌。卵巢癌和女性肛门癌与男性乳腺癌的关联最强（p 值<0.0005）。其他显著关联包括结直肠癌、小肠癌和甲状腺癌、不明原发性癌症和非霍奇金淋巴瘤，但这些关联均基于与男性乳腺癌的单一阳性关联。有多个家庭成员被诊断患有多种癌症的家庭中，男性乳腺癌的 RR 增加，当三个或更多家庭成员受到影响时，RR 达到 2.58。
结果表明，男性乳腺癌与多种其他癌症具有相似的易感性，但需要在其他数据集进行证实。
