Lamy Pierre-Jean, Trétarre Brigitte, Rebillard Xavier, Sanchez Marie, Cénée Sylvie, Ménégaux Florence
Service Urologie, Clinique Beau Soleil, Montpellier, France.
Institut d'Analyse Génomique-Imagenome, Labosud, Montpellier, France.
Oncotarget. 2018 May 4;9(34):23661-23669. doi: 10.18632/oncotarget.25320.
Familial aggregation is now well established with an increased risk of prostate cancer in patients with a family history of prostate cancer in first degree relatives. The aim of this paper was to investigate the role of family history of cancer in first degree relatives in prostate cancer risk.
As expected, a family history of prostate cancer in first-degree relatives was more frequent in cases than in controls (OR 3.10, 95% CI 2.32-4.15). A family history of early BCa (before age 50) in first-degree relatives was more frequent in cases than in controls (OR 1.79, 95% CI 1.09-2.94) with higher risk of aggressive PCa. The association was more pronounced for BCa in daughters (OR 15.26 95% CI 1.95-120).
In summary, a family history of BCa in first degree relatives before age 50 may increases the risk of PCa with higher Gleason score. This finding could suggest a specific prostate surveillance and/or genetic counselling for men who present such familial history.
EPIdemiological study of Prostate CAncer (EPICAP) is a population-based case-control study specifically designed to investigate the role of environmental and genetic factors in prostate cancer. Detailed information on family history of cancer in first degree relatives (parents, brothers and sisters, children) was collected as well as the age of occurrence and the localization of each cancer. Overall, 819 cases and 879 controls have been included.
家族聚集现象现已得到充分证实，一级亲属中有前列腺癌家族史的患者患前列腺癌的风险会增加。本文旨在研究一级亲属的癌症家族史在前列腺癌风险中的作用。
正如预期的那样，病例组中一级亲属有前列腺癌家族史的情况比对照组更为常见（比值比3.10，95%置信区间2.32 - 4.15）。一级亲属中有早期乳腺癌（50岁之前）家族史的情况在病例组中比对照组更为常见（比值比1.79，95%置信区间1.09 - 2.94），侵袭性前列腺癌的风险更高。女儿患乳腺癌的家族史与前列腺癌的关联更为显著（比值比15.26，95%置信区间1.95 - 120）。
总之，50岁之前一级亲属中有乳腺癌家族史可能会增加 Gleason 评分较高的前列腺癌的风险。这一发现可能提示对有此类家族史的男性进行特定的前列腺监测和/或遗传咨询。
前列腺癌流行病学研究（EPICAP）是一项基于人群的病例对照研究，专门设计用于调查环境和遗传因素在前列腺癌中的作用。收集了一级亲属（父母、兄弟姐妹、子女）癌症家族史的详细信息，以及每种癌症的发病年龄和发病部位。总体而言，共纳入了819例病例和879例对照。
