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姜辣素在链脲佐菌素诱导的糖尿病大鼠模型中的心脏保护作用以及显著的抗糖尿病心肌病作用

Cardio-Protective Role of Gingerol along with Prominent Anti-Diabetic Cardiomyopathy Action in A Streptozotocin-Induced Diabetes Mellitus Rat Model.

作者信息

Yu Li-Ya, Shi Wen-Lei, Guo Xin-GuiGuo

机构信息

Department of Cardiology, Huadong Hospital, Fudan University, Shanghai, China.

出版信息

Cell J. 2017 Oct;19(3):469-475. doi: 10.22074/cellj.2017.4509. Epub 2017 Aug 19.

DOI:10.22074/cellj.2017.4509
PMID:28836409
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5570412/
Abstract

OBJECTIVES

Diabetic cardiomyopathy (DCM) is characterized as a coronary heart disease which expands during diabetes due to alterations in the myocardial function and structure. The currentstudy intends to elucidate the protective effect of gingerol on DCM in a streptozotocin (STZ)-induced diabetes mellitus (DM) rat model.

MATERIALS AND METHODS

In this experimental study, the animals were divided into three groups: normal control, DM control, and DM+gingerol (10 mg/kg). The body weights of all rats were estimated at regular intervals. The myocardial profile, oxidative stress, and activities of metabolic enzymes were also scrutinized. The proinflammatory cytokine levels together with cellular protein expression connected with apoptosis were estimated via Western blot analysis.

RESULTS

The rats that suffered from DCM exhibited abnormal levels of myocardial markers, aberrant metabolic enzymatic activity, elevated concentrations of inflammatory factors, and enhanced oxidative stress parameters along with increased cell death apoptosis. Whereas gingerol showed protective effects on the treated rats by an improved antioxidant defense system.

CONCLUSIONS

The current findings suggested that gingerol is effective in the treatment of DCM by inhibition of inflammation and oxidative stress.

摘要

目的

糖尿病性心肌病（DCM）的特征是一种在糖尿病期间由于心肌功能和结构改变而发展的冠心病。本研究旨在阐明姜辣素对链脲佐菌素（STZ）诱导的糖尿病（DM）大鼠模型中DCM的保护作用。

材料与方法

在本实验研究中，将动物分为三组：正常对照组、糖尿病对照组和糖尿病+姜辣素（10mg/kg）组。定期评估所有大鼠的体重。还对心肌状况、氧化应激和代谢酶活性进行了检查。通过蛋白质免疫印迹分析评估促炎细胞因子水平以及与细胞凋亡相关的细胞蛋白表达。

结果

患有DCM的大鼠表现出心肌标志物水平异常、代谢酶活性异常、炎症因子浓度升高、氧化应激参数增强以及细胞死亡凋亡增加。而姜辣素通过改善抗氧化防御系统对治疗的大鼠显示出保护作用。

结论

目前的研究结果表明，姜辣素通过抑制炎症和氧化应激对DCM治疗有效。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac85/5570412/baef08f19fbe/Cell-J-19-469-g08.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac85/5570412/7d3a46979318/Cell-J-19-469-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac85/5570412/e058131028bf/Cell-J-19-469-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac85/5570412/3160e17b6044/Cell-J-19-469-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac85/5570412/c852e12b00c7/Cell-J-19-469-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac85/5570412/6430cdd3b7b2/Cell-J-19-469-g05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac85/5570412/b2d5fa59a339/Cell-J-19-469-g06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac85/5570412/68ce961fe543/Cell-J-19-469-g07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac85/5570412/baef08f19fbe/Cell-J-19-469-g08.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac85/5570412/7d3a46979318/Cell-J-19-469-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac85/5570412/e058131028bf/Cell-J-19-469-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac85/5570412/3160e17b6044/Cell-J-19-469-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac85/5570412/c852e12b00c7/Cell-J-19-469-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac85/5570412/6430cdd3b7b2/Cell-J-19-469-g05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac85/5570412/b2d5fa59a339/Cell-J-19-469-g06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac85/5570412/68ce961fe543/Cell-J-19-469-g07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac85/5570412/baef08f19fbe/Cell-J-19-469-g08.jpg

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