文献检索文档翻译深度研究
Suppr Zotero 插件Zotero 插件
邀请有礼套餐&价格历史记录

新学期，新优惠

限时优惠:9月1日-9月22日

30天高级会员仅需29元

1天体验卡首发特惠仅需5.99元

了解详情
不再提醒
插件&应用
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
高级版
套餐订阅购买积分包
AI 工具
文献检索文档翻译深度研究
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2025

6-姜酚，生姜的一种生物活性化合物，通过调节氧化应激和炎症减轻链脲佐菌素诱导的糖尿病大鼠的肾损伤。

6-Gingerol, a Bioactive Compound of Ginger Attenuates Renal Damage in Streptozotocin-Induced Diabetic Rats by Regulating the Oxidative Stress and Inflammation.

作者信息

Almatroodi Saleh A, Alnuqaydan Abdullah M, Babiker Ali Yousif, Almogbel Mashael Abdullah, Khan Amjad Ali, Husain Rahmani Arshad

机构信息

Department of Medical Laboratories, College of Applied Medical Sciences, Qassim University, Buraydah 51452, Saudi Arabia.

Department of Medical Biotechnology, College of Applied Medical Sciences, Qassim University, Buraydah 51452, Saudi Arabia.

出版信息

Pharmaceutics. 2021 Feb 28;13(3):317. doi: 10.3390/pharmaceutics13030317.

DOI:10.3390/pharmaceutics13030317
PMID:33670981
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7997342/
Abstract

The aim of present study is to investigate the role of 6-gingerol in ameliorating the renal injury in streptozotocin (STZ)-induced diabetic rats. The diabetes was induced by using a single dose of freshly prepared STZ (55 mg/kg body weight) intraperitoneally which causes the degeneration of pancreatic Langerhans islet β-cells. The diabetic rats were treated with oral gavage of 6-gingerol (10 mg/kg b.w.). The treatment plan was continued for 8 weeks successively and the body weight and fasting blood glucose levels were weekly checked. The biochemical parameters like lipid profile, kidney profile, antioxidant enzyme levels, lipid peroxidation and anti-inflammatory marker levels were investigated after the treatment plant. The pathological condition of kidneys was examined by haematoxylin-eosin (H&E) staining besides this analysis of NF-B protein expression by immuno-histochemistry was performed. Some of the major parameters in diabetes control vs. normal control were reported as fasting blood glucose (234 ± 10 vs. 102 ± 8 mg/dL), serum creatinine (109.7 ± 7.2 vs. 78.9 ± 4.5 μmol/L) and urea (39.9 ± 1.8 vs. 18.6 mg/dL), lipid profile levels were significantly enhanced in diabetic rats. Moreover, diabetic rats were marked with decreased antioxidant enzyme levels and increased inflammatory markers. Treatment with 6-gingerol significantly restored the fasting blood glucose level, hyperlipidaemia, () and inflammatory marker levels, NF-B protein expression and augmented the antioxidant enzyme levels in the kidneys of diabetic rats. The kidney damage was significantly normalized by the treatment of 6-gingerol and it provides an evidence that this novel compound plays a significant role in the protection of kidney damage. These findings demonstrate that 6-gingerol reduces lipid parameters, inflammation and oxidative stress in diabetic rats, thereby inhibiting the renal damage. Our results demonstrate that use of 6-gingerol could be a novel therapeutic approach to prevent the kidney damage associated with the diabetes mellitus.

摘要

本研究的目的是探讨6-姜酚在改善链脲佐菌素（STZ）诱导的糖尿病大鼠肾损伤中的作用。通过腹腔注射单剂量新鲜配制的STZ（55mg/kg体重）诱导糖尿病，这会导致胰腺朗格汉斯胰岛β细胞变性。给糖尿病大鼠口服灌胃6-姜酚（10mg/kg体重）。连续8周持续该治疗方案，并每周检查体重和空腹血糖水平。治疗方案结束后，研究脂质谱、肾脏指标、抗氧化酶水平、脂质过氧化和抗炎标志物水平等生化参数。除了通过免疫组织化学分析NF-κB蛋白表达外，还用苏木精-伊红（H&E）染色检查肾脏的病理状况。与正常对照组相比，糖尿病对照组的一些主要参数如下：空腹血糖（234±10 vs. 102±8mg/dL）、血清肌酐（109.7±7.2 vs. 78.9±4.5μmol/L）和尿素（39.9±1.8 vs. 18.6mg/dL），糖尿病大鼠的脂质谱水平显著升高。此外，糖尿病大鼠的抗氧化酶水平降低，炎症标志物增加。用6-姜酚治疗可显著恢复糖尿病大鼠肾脏的空腹血糖水平、高脂血症、（此处原文缺失内容）和炎症标志物水平、NF-κB蛋白表达，并提高抗氧化酶水平。6-姜酚治疗可使肾脏损伤明显恢复正常，这证明这种新型化合物在保护肾脏损伤中起重要作用。这些发现表明，6-姜酚可降低糖尿病大鼠的脂质参数、炎症和氧化应激，从而抑制肾脏损伤。我们的结果表明，使用6-姜酚可能是预防糖尿病相关肾脏损伤的一种新型治疗方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6178/7997342/2f8bc30d24b2/pharmaceutics-13-00317-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6178/7997342/17508b7f49e5/pharmaceutics-13-00317-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6178/7997342/b4f82b862188/pharmaceutics-13-00317-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6178/7997342/26d80f3a458b/pharmaceutics-13-00317-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6178/7997342/0c544602362d/pharmaceutics-13-00317-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6178/7997342/5a8d098ace7a/pharmaceutics-13-00317-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6178/7997342/21023452de7c/pharmaceutics-13-00317-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6178/7997342/b31763aabf1c/pharmaceutics-13-00317-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6178/7997342/2f8bc30d24b2/pharmaceutics-13-00317-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6178/7997342/17508b7f49e5/pharmaceutics-13-00317-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6178/7997342/b4f82b862188/pharmaceutics-13-00317-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6178/7997342/26d80f3a458b/pharmaceutics-13-00317-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6178/7997342/0c544602362d/pharmaceutics-13-00317-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6178/7997342/5a8d098ace7a/pharmaceutics-13-00317-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6178/7997342/21023452de7c/pharmaceutics-13-00317-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6178/7997342/b31763aabf1c/pharmaceutics-13-00317-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6178/7997342/2f8bc30d24b2/pharmaceutics-13-00317-g008.jpg

相似文献

[1]
6-Gingerol, a Bioactive Compound of Ginger Attenuates Renal Damage in Streptozotocin-Induced Diabetic Rats by Regulating the Oxidative Stress and Inflammation.

Pharmaceutics. 2021-2-28

[2]
Anti-inflammatory and renal protective effect of gingerol in high-fat diet/streptozotocin-induced diabetic rats via inflammatory mechanism.

Inflammopharmacology. 2019-3-2

[3]
Quercetin, a Plant Flavonol Attenuates Diabetic Complications, Renal Tissue Damage, Renal Oxidative Stress and Inflammation in Streptozotocin-Induced Diabetic Rats.

Metabolites. 2023-1-15

[4]
The modulatory role of prime identified compounds in the bioactive fraction of Homalium zeylanicum in high-fat diet fed-streptozotocin-induced type 2 diabetic rats.

J Ethnopharmacol. 2020-10-5

[5]
Diltiazem attenuates oxidative stress in diabetic rats.

Ren Fail. 2005

[6]
6-Gingerol, a Major Ingredient of Ginger Attenuates -Induced Liver Injury in Rats through the Modulation of Oxidative Stress and Anti-Inflammatory Activity.

Mediators Inflamm. 2021

[7]
Effects of Nigella sativa on oxidative stress and beta-cell damage in streptozotocin-induced diabetic rats.

Anat Rec A Discov Mol Cell Evol Biol. 2004-7

[8]
Quercetin, a flavonoid antioxidant, prevents and protects streptozotocin-induced oxidative stress and beta-cell damage in rat pancreas.

Pharmacol Res. 2005-2

[9]
Effects of enalapril and paricalcitol treatment on diabetic nephropathy and renal expressions of TNF-α, p53, caspase-3 and Bcl-2 in STZ-induced diabetic rats.

PLoS One. 2019-9-17

[10]
BAY 11-7082 ameliorates diabetic nephropathy by attenuating hyperglycemia-mediated oxidative stress and renal inflammation via NF-κB pathway.

Environ Toxicol Pharmacol. 2015-3

引用本文的文献

[1]
Anti-inflammatory effects of 6-gingerol on arthritis in rats by inhibition of the NF-kB TAB1 signaling pathway.

Inflammopharmacology. 2025-9-1

[2]
Natural Products as Modulators of Iron Metabolism and Ferroptosis in Diabetes and Its Complications.

Nutrients. 2025-8-21

[3]
Insights into biological activities profile of gingerols and shogaols for potential pharmacological applications.

Arch Pharm Res. 2025-8

[4]
Unlocking the Pharmacological Potential of Myricetin Against Various Pathogenesis.

Int J Mol Sci. 2025-4-28

[5]
Mechanisms of ferroptotic and non-ferroptotic organ toxicity of chemotherapy: protective and therapeutic effects of ginger, 6-gingerol and zingerone in preclinical studies.

Naunyn Schmiedebergs Arch Pharmacol. 2025-5

[6]
Renoprotective effect of a novel combination of 6-gingerol and metformin in high-fat diet/streptozotocin-induced diabetic nephropathy in rats via targeting miRNA-146a, miRNA-223, TLR4/TRAF6/NLRP3 inflammasome pathway and HIF-1α.

Biol Res. 2024-7-20

[7]
Apigenin: A Bioflavonoid with a Promising Role in Disease Prevention and Treatment.

Biomedicines. 2024-6-18

[8]
protective effects of 6‑gingerol in cerebral ischemia involve preservation of antioxidant defenses and activation of anti‑apoptotic pathways.

Biomed Rep. 2024-4-4

[9]
Natural compounds proposed for the management of non-alcoholic fatty liver disease.

Nat Prod Bioprospect. 2024-4-1

[10]
The molecular mechanism of "Dahuang-Shengjiang-Banxia decoction" in the treatment of diabetic kidney disease was verified based on network pharmacology and molecular docking.

Heliyon. 2024-1-19

本文引用的文献

[1]
6-Gingerol, a Major Ingredient of Ginger Attenuates -Induced Liver Injury in Rats through the Modulation of Oxidative Stress and Anti-Inflammatory Activity.

Mediators Inflamm. 2021

[2]
Epigallocatechin-3-Gallate (EGCG), an Active Compound of Green Tea Attenuates Acute Lung Injury Regulating Macrophage Polarization and Krüpple-Like-Factor 4 (KLF4) Expression.

Molecules. 2020-6-20

[3]
Mangiferin Alleviates Renal Interstitial Fibrosis in Streptozotocin-Induced Diabetic Mice through Regulating the PTEN/PI3K/Akt Signaling Pathway.

J Diabetes Res. 2020-1-31

[4]
Curcumin, an Active Constituent of Turmeric Spice: Implication in the Prevention of Lung Injury Induced by Benzo(a) Pyrene (BaP) in Rats.

Molecules. 2020-2-7

[5]
Anti-inflammatory and renal protective effect of gingerol in high-fat diet/streptozotocin-induced diabetic rats via inflammatory mechanism.

Inflammopharmacology. 2019-3-2

[6]
A brief review about melatonin, a pineal hormone.

Arch Endocrinol Metab. 2018-8

[7]
Ursolic acid improves diabetic nephropathy via suppression of oxidative stress and inflammation in streptozotocin-induced rats.

Biomed Pharmacother. 2018-6-19

[8]
Ginger alleviates hyperglycemia-induced oxidative stress, inflammation and apoptosis and protects rats against diabetic nephropathy.

Biomed Pharmacother. 2018-7-11

[9]
Oxidative Stress, Apoptosis, and Mitochondrial Function in Diabetic Nephropathy.

Int J Endocrinol. 2018-4-1

[10]
Neuroprotective Effect and Molecular Mechanism of [6]-Gingerol against Scopolamine-Induced Amnesia in C57BL/6 Mice.

Evid Based Complement Alternat Med. 2018-1-31

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

推荐工具

医学文档翻译智能文献检索