Johanson C E
Pharmacol Biochem Behav. 1987 Mar;26(3):521-6. doi: 10.1016/0091-3057(87)90159-6.
The ability of three benzodiazepines to maintain self-administration behavior was studied in rhesus monkeys using a substitution procedure. Lever-press responding was maintained in six monkeys under a fixed-ratio schedule of IV pentobarbital delivery in daily sessions of 3 hr duration. Each of several doses of flurazepam, lorazepam and estazolam as well as saline and vehicle was periodically substituted for 4-13 consecutive sessions. Between dose or vehicle substitutions, responding was maintained by pentobarbital. All six monkeys self-administered flurazepam above vehicle or saline levels. In addition four of five monkeys tested with lorazepam and four of six tested with estazolam self-administered at least one dose of drug above control levels. These results indicate that self-administration performance can be reliably maintained in rhesus monkeys by certain benzodiazepines under appropriate experimental conditions.
采用替代程序，在恒河猴中研究了三种苯二氮䓬类药物维持自我给药行为的能力。在每日时长为3小时的实验中，六只猴子在静脉注射戊巴比妥的固定比率程序下保持杠杆按压反应。几种剂量的氟西泮、劳拉西泮和艾司唑仑以及生理盐水和赋形剂会周期性地连续替代4 - 13个实验时段。在剂量或赋形剂替代之间，由戊巴比妥维持反应。所有六只猴子自我给药的氟西泮量均高于赋形剂或生理盐水水平。此外，在接受劳拉西泮测试的五只猴子中，有四只，在接受艾司唑仑测试的六只猴子中，有四只自我给药的药物剂量至少高于对照水平一剂。这些结果表明，在适当的实验条件下，某些苯二氮䓬类药物能够在恒河猴中可靠地维持自我给药行为。
