Zegers-Hochschild Fernando, Schwarze Juan Enrique, Crosby Javier A, Musri Carolina, Urbina Maria Teresa
Reproductive Medicine Unit - Las Condes Clinic, Chile.
Ethics and Public Policies Program in Human Reproduction, University Diego Portales, Chile.
JBRA Assist Reprod. 2017 Sep 1;21(3):164-175. doi: 10.5935/1518-0557.20170034.
Multinational data on assisted reproduction techniques undertaken in 2014 were collected from 159 institutions in 15 countries in Latin America. Treatments included IVF/ ICSI, FET, OD, PGD and fertility preservation (FP). 41.34% of IVF/ICSI cycles were performed in women aged 35 to 39 years and 23.35% in women aged 40 and older. After removing cases with total freezing, delivery rate per oocyte retrieval was 25.05% for ICSI and 27.41% for IVF. Multiple births included 20.78% twins and 0.92 % triplets and over. In OD, twins reached 28.93% and triplets 1.07 %. Preterm deliveries reached 16.4% in singletons, 55.02% in twins and 76% in triplets. Perinatal mortality in 18,162 births was 23 per 1000 in singletons, 35 per 1000 in twins, and 36 per 1000 in high-order multiples. Elective single embryo transfer (eSET) represented only 2.63 % of fresh transfers, with a delivery rate of 32.15% per transfer. Elective double embryo transfer (eDET) represented 23.74% of transfers, with a delivery rate of 41.03% per transfer. Among babies born during this period 11,373 (62.6%) were singletons; 6,398 (35.2%) twins, and 391 (2.2%), triplets and more. Given the effect of multiple births on prematurity, morbidity and perinatal mortality, reinforcing the existing trend of reducing the number of embryos transferred is mandatory.
2014年拉丁美洲15个国家159家机构收集了辅助生殖技术的跨国数据。治疗方法包括体外受精/卵胞浆内单精子注射(IVF/ICSI)、冻融胚胎移植(FET)、卵巢刺激(OD)、植入前基因诊断(PGD)和生育力保存(FP)。41.34%的IVF/ICSI周期是在35至39岁的女性中进行的,23.35%是在40岁及以上的女性中进行的。去除全部冷冻的病例后,ICSI每取卵周期的分娩率为25.05%,IVF为27.41%。多胎妊娠包括20.78%的双胞胎和0.92%的三胞胎及以上。在卵巢刺激中,双胞胎率达28.93%,三胞胎率为1.07%。单胎早产率达16.4%,双胞胎为55.02%,三胞胎为76%。18162例分娩中的围产期死亡率,单胎为每1000例23例,双胞胎为每1000例35例,高阶多胎为每1000例36例。选择性单胚胎移植(eSET)仅占新鲜移植的2.63%,每次移植的分娩率为32.15%。选择性双胚胎移植(eDET)占移植的23.74%,每次移植的分娩率为41.03%。在此期间出生的婴儿中,11373例(62.6%)为单胎;6398例(35.2%)为双胞胎,391例(2.2%)为三胞胎及以上。鉴于多胎妊娠对早产、发病率和围产期死亡率的影响,强化现有减少移植胚胎数量的趋势是必要的。