目前支持单胎妊娠目标的证据：体外受精和胞浆内单精子注射后双胎与单胎妊娠相关的母婴围产结局的综述。
Current evidence supporting a goal of singletons: a review of maternal and perinatal outcomes associated with twin versus singleton pregnancies after in vitro fertilization and intracytoplasmic sperm injection.
机构信息
Department of Obstetrics and Gynecology, University of Iowa, Iowa City, Iowa.
Department of Obstetrics and Gynecology, University of Iowa, Iowa City, Iowa.
出版信息
Fertil Steril. 2020 Oct;114(4):690-714. doi: 10.1016/j.fertnstert.2020.08.1423.
Abstract
With increasing use of in vitro fertilization and intracytoplasmic sperm injection (IVF-ICSI) almost 2% of all babies born in the United States each year are now conceived with these technologies, making outcomes of IVF-ICSI extremely important not only to patients and families but to public health. Twin pregnancy rates after IVF-ICSI in the United States have declined since their peak in 2013 but remain at approximately 1 in 10 to 1 in 20 pregnancies. A review of the current international literature on twin versus singleton pregnancy outcomes after IVF-ICSI treatment confirms statistically significantly higher risks to maternal and perinatal health and statistically significantly higher health care costs. The field of infertility care should continue to work to develop practices that lower twin pregnancy rates to an absolute minimum to maximize the safety of these medical treatments.
摘要
随着体外受精和胞浆内单精子注射（IVF-ICSI）的应用日益增多，美国每年出生的婴儿中现在几乎有 2%是通过这些技术孕育的，因此，IVF-ICSI 的结果不仅对患者及其家庭，而且对公共卫生都极为重要。自 2013 年达到峰值以来，美国 IVF-ICSI 后的双胞胎妊娠率有所下降，但仍约为每 10 至 20 次妊娠中有 1 次双胞胎。对 IVF-ICSI 治疗后双胞胎与单胎妊娠结局的当前国际文献进行综述，证实母婴和围产期健康的风险显著增加，并且医疗保健费用显著增加。不孕不育治疗领域应继续努力，将双胞胎妊娠率降低到绝对最低水平，以最大限度地提高这些医疗治疗的安全性。
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