拉丁美洲的辅助生殖技术（ART）：2012年拉丁美洲登记处

Assisted Reproductive Technologies (ART) in Latin America: The Latin American Registry, 2012.

作者信息

Zegers-Hochschild Fernando, Schwarze Juan Enrique, Crosby Javier A, Musri Carolina, Souza Maria do Carmo B de

机构信息

Unit of Reproductive Medicine Clínica Las Condes, Chile.

Program of Ethics and Public Policies in Human Reproduction, University Diego Portales, Chile.

出版信息

JBRA Assist Reprod. 2014 Dec 27;18(4):127-135. doi: 10.5935/1518-0557.20140018.

DOI:10.5935/1518-0557.20140018

PMID:35761740

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9239415/

Abstract

OBJECTIVE

This report examines information on Assisted Reproduction Technologies performed in Latin America (LA) during 2012.

METHODS

Multinational data were collected directly from 155 institutions in 14 countries. Individualized, case-bycase data include 47,326 ART cycles covering more than 80% of cycles performed in LA. Treatments included in vitro fertilization (IVF), intracytoplasmic sperm injection (ICSI), frozen embryo transfers (FET), oocyte donations (OD) and fertility preservation.

RESULTS

In 39% of ET IVF/ICSI was performed in women age 35-39 and 31% in women ≥40 years. Delivery rate (DR) per pick-up (OPU) in ICSI and IVF cycles, were 20.9% and 26.5%, respectively. Overall multiple births comprised 20.6% twins and 1.2% triplets. Furthermore, in OD, twins and triplets reached 27.8% and 2.4%, respectively. Pre term births in singletons were 14%. The relative risk of prematurity increased by 4.30 (95% CI 4.1-4.6) in twins, and 43.8 (95% CI 28.5-67.4) in ≥ triplets. Perinatal mortality increased from 25.2‰ in singletons, to 44.0‰ in twins and 80‰ in ≥ triplets. Elective single embryo transfer (eSET) was performed in only 1.4% of cycles with DR of 30% in women ≤34 years.

CONCLUSION

Trends over the last 20 years show that eSET should be the way to go provided access is facilitated with public funding.

摘要

目的

本报告研究了2012年拉丁美洲（LA）辅助生殖技术的相关信息。

方法

直接从14个国家的155个机构收集跨国数据。个体化的逐案数据包括47326个辅助生殖技术周期，涵盖了LA地区超过80%的已实施周期。治疗方法包括体外受精（IVF）、卵胞浆内单精子注射（ICSI）、冻融胚胎移植（FET）、卵母细胞捐赠（OD）和生育力保存。

结果

在39%的胚胎移植中，IVF/ICSI是在35 - 39岁的女性中进行的，31%是在40岁及以上的女性中进行的。ICSI和IVF周期中每次取卵（OPU）的分娩率（DR）分别为20.9%和26.5%。总体多胎妊娠中，双胞胎占20.6%，三胞胎占1.2%。此外，在卵母细胞捐赠中，双胞胎和三胞胎分别达到27.8%和2.4%。单胎早产率为14%。双胞胎早产的相对风险增加了4.30（95%可信区间4.1 - 4.6），三胞胎及以上则增加了43.8（95%可信区间28.5 - 67.4）。围产期死亡率从单胎的25.2‰增加到双胞胎的44.0‰，三胞胎及以上的为80‰。仅1.4%的周期进行了选择性单胚胎移植（eSET），34岁及以下女性的分娩率为30%。