Department of Chemistry, The University of Texas at El Paso, El Paso, TX 79968, USA.
Environmental Science and Engineering Program, The University of Texas at El Paso, El Paso, TX 79968, USA.
Molecules. 2017 Aug 24;22(9):1397. doi: 10.3390/molecules22091397.
Halogen bonding has emerged at the forefront of advances in improving ligand: receptor interactions. In particular the newfound ability of this extant non-covalent-bonding phenomena has revolutionized computational approaches to drug discovery while simultaneously reenergizing synthetic approaches to the field. Here we survey, via examples of classical applications involving halogen atoms in pharmaceutical compounds and their biological hosts, the unique advantages that halogen atoms offer as both Lewis acids and Lewis bases.
卤键在改善配体-受体相互作用的研究中处于前沿地位。特别是这种新发现的非共价键现象，不仅彻底改变了药物发现的计算方法，也为该领域的合成方法带来了新的活力。通过涉及药物化合物及其生物主体中卤原子的经典应用实例，本文综述了卤原子作为路易斯酸和路易斯碱的独特优势。
