使用定量三维磁共振成像对伴有和不伴有胎儿多普勒变化的生长受限胎儿的胎盘和脑容量进行体内评估。
In vivo assessment of placental and brain volumes in growth-restricted fetuses with and without fetal Doppler changes using quantitative 3D MRI.
作者信息
Andescavage N, duPlessis A, Metzler M, Bulas D, Vezina G, Jacobs M, Iqbal S N, Baschat A, Limperopoulos C
机构信息
Division of Neonatology, Children's National Health System, Washington, DC, USA.
Department of Pediatrics, George Washington University School of Medicine, Washington, DC, USA.
出版信息
J Perinatol. 2017 Dec;37(12):1278-1284. doi: 10.1038/jp.2017.129. Epub 2017 Aug 24.
OBJECTIVE
The relationship between placental and fetal brain growth is poorly understood and difficult to assess. The objective of this study was to interrogate placental and fetal brain growth in healthy pregnancies and those complicated by fetal growth restriction (FGR).
STUDY DESIGN
In a prospective, observational study, pregnant women with normal pregnancies or pregnancies complicated by FGR underwent fetal magnetic resonance imaging (MRI). Placental, global and regional brain volumes were calculated.
RESULTS
A total of 114 women (79 controls and 35 FGR) underwent MRI (median gestational age (GA) 30 weeks, range 18 to 39). All measured volumes increased exponentially with advancing GA. Placental, total brain, cerebral and cerebellar volumes were smaller in FGR compared with controls (P<0.05). Increasing placental volume was associated with increasing cerebral and cerebellar volumes (P<0.05).
CONCLUSION
Quantitative fetal MRI can accurately detect decreased placental and brain volumes in pregnancies with FGR and may provide insight into the timing and mechanisms of brain injury in FGR.
目的
胎盘与胎儿大脑生长之间的关系目前了解甚少且难以评估。本研究的目的是探究健康妊娠以及合并胎儿生长受限（FGR）的妊娠中胎盘和胎儿大脑的生长情况。
研究设计
在一项前瞻性观察性研究中，正常妊娠或合并FGR的孕妇接受了胎儿磁共振成像（MRI）检查。计算胎盘、全脑和脑区的体积。
结果
共有114名女性（79名对照组和35名FGR组）接受了MRI检查（中位孕周（GA）为30周，范围为18至39周）。所有测量的体积均随孕周增加呈指数增长。与对照组相比，FGR组的胎盘、全脑、大脑和小脑体积较小（P<0.05）。胎盘体积增加与大脑和小脑体积增加相关（P<0.05）。
结论
定量胎儿MRI能够准确检测出合并FGR的妊娠中胎盘和脑体积减小，并可能为了解FGR中脑损伤的时间和机制提供线索。
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